DNMT


Also found in: Acronyms.

DNMT

This is the retired HUGO symbol for what is now designated DNMT1.
References in periodicals archive ?
DNMTs, for instance, represent a portion of one's internal environment, while toxins or toxic conditions represent the external environment.
And also, it will replace nucleoside during DNA proliferation which will disable DNMT and causes DNMTs degradation.
It is likely that the level of 5hmC is affected by multiple mechanisms, including suppression of TET1 and overexpression of DNMT.
DNMT 3A and DNMT 3B are referred to as de novo methyltransferases because they target unmethylated CpGs.
After fertilization and before implantation, DNA methylation patterns are largely erased but are reestablished by de novo DNMTs in the blastocyst stage (Jirtle and Skinner 2007).
The NNK-induced DNMT proteins would bind with the tumor suppressor genes, inducing the overexpression of DNA methyltranferase 1.
Of these, DNMT3A and 3B primarily perform de novo methyl transfer, whereas DNMT1 mainly acts as maintenance DNMT with greater affinity for partially methylated (i.
We observed a significant reduction in expression of DNMT proteins after treatment without changes in messenger RNA.
In neural cell cultures, alcohol-induced downregulation of cell-cycle genes was paralleled by an increased DNMT activity and hypermethylation of the promoters of those genes (Hicks et al.
Estrogen receptor genes are found to be silenced, or turned off, in human breast cancer cells and thus the reactivation of these genes using HDAC and DNMT inhibitors may provide insight in developing drug targets to treat breast cancer.
SssI DNMT (a bacterial DNMT that recognizes the same sequence as mammalian DNMTs) showed that cadmium exposure was an effective, noncompetitive inhibitor of DNMT (Takiguchi et al.