DNAzyme

(dē-ĕn-ā′zīm″) [″ + (en)zyme]

A string of linked nucleotides capable of catalyzing a biochemical reaction.

References in periodicals archive ?

KG has presented positive data from the SECURE study, a Phase 2a trial in patients with moderate to severe ulcerative colitis treated with its GATA-3 specific DNAzyme formulation SB012, at the 13th Congress of the European Crohn's and Colitis Organisation (ECCO), the company said.

Sterna Biologicals Presents Results of Efficacy Study of GATA-3 Antagonist for Treatment of Ulcerative Colitis at ECCO Meeting

Germany-based sterna biological has revealed positive results from the SECURE study, a Phase 2a trial in patients with moderate to severe ulcerative colitis treated with the company's GATA-3 specific DNAzyme formulation, SB012, it was reported yesterday.

sterna biological reveals positive results from SECURE study of SB012

Recognition elements respond to fusion gene logically, whereas the responses regulate the "open" and "closed" states of the tweeters and further regulate the "inactive" and "active" states of the DNAzyme. The activated DNAzymes successively cleave the fluorescence substrates, thus enabling the intelligent and sensitive detection of fusion events without the attending of any native enzyme.

DNA Nanotweezers with Hydrolytic Activity for Enzyme-Free and Sensitive Detection of Fusion Gene via Logic Operation

Perrin, "A highly selective DNAzyme sensor for mercuric ions," Angewandte Chemie International Edition, vol.

Ion-Imprinted Polymer-Based Receptors for Sensitive and Selective Detection of Mercury Ions in Aqueous Environment

There are three components to this technology: a microfluidic droplet generator, a particle counter system, and a bacterial detection method that utilizes DNAzyme sensor technology.

New technologies for diagnosing bloodstream infection and measuring antimicrobial resistance: part II: emerging technologies in research and development

Zhang, "A folate receptor electrochemical sensor based on terminal protection and supersandwich DNAzyme amplification," Biosensors and Bioelectronics, vol.

Rapid and Selective Determination of Folate Receptor a with Sensitive Resonance Rayleigh Scattering Signal

Lu, "Label-free colorimetric detection of lead ions with a nanomolar detection limit and tunable dynamic range by using gold nanoparticles and DNAzyme," Advanced Materials, vol.

Hybridization State Detection of DNA-Functionalized Gold Nanoparticles Using Hyperspectral Imaging

Bellocq et al., "Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles," Cancer Biology and Therapy, vol.

Targeted Delivery of siRNA Therapeutics to Malignant Tumors

DNAzyme, also known as deoxyribozyme, refers to a guanine-rich nucleic acid sequence with catalytic capabilities similar to common enzymes [13].

Optimization of Anatoxin B1 Aptasensing. (Research Article)

Zhou, "The sensitive and selective optical detection of mercury(II) ions by using a phosphorothioate DNAzyme strategy," Chemistry--A European Journal, vol.

Application of Starch-Stabilized Silver Nanoparticles as a Colorimetric Sensor for Mercury(II) in 0.005 mol/L Nitric Acid

Using an Egr1 antisense oligodeoxy ribonucleotide or a catalytic deoxyribonucleic acid molecule (DNAzyme) to inhibit Egr-1 has been shown to reduce myocardial inflammation and protect heart function against the I/R [11, 13].

ERK1/2-Egr-1 signaling pathway-mediated protective effects of electroacupuncture in a mouse model of myocardial ischemia-reperfusion

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