KG has presented positive data from the SECURE study, a Phase 2a trial in patients with moderate to severe ulcerative colitis treated with its GATA-3 specific DNAzyme
formulation SB012, at the 13th Congress of the European Crohn's and Colitis Organisation (ECCO), the company said.
Germany-based sterna biological has revealed positive results from the SECURE study, a Phase 2a trial in patients with moderate to severe ulcerative colitis treated with the company's GATA-3 specific DNAzyme
formulation, SB012, it was reported yesterday.
Recognition elements respond to fusion gene logically, whereas the responses regulate the "open" and "closed" states of the tweeters and further regulate the "inactive" and "active" states of the DNAzyme
. The activated DNAzymes
successively cleave the fluorescence substrates, thus enabling the intelligent and sensitive detection of fusion events without the attending of any native enzyme.
Perrin, "A highly selective DNAzyme
sensor for mercuric ions," Angewandte Chemie International Edition, vol.
There are three components to this technology: a microfluidic droplet generator, a particle counter system, and a bacterial detection method that utilizes DNAzyme
Zhang, "A folate receptor electrochemical sensor based on terminal protection and supersandwich DNAzyme
amplification," Biosensors and Bioelectronics, vol.
Lu, "Label-free colorimetric detection of lead ions with a nanomolar detection limit and tunable dynamic range by using gold nanoparticles and DNAzyme
," Advanced Materials, vol.
Bellocq et al., "Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme
) to tumor tissue by transferrin-modified, cyclodextrin-based particles," Cancer Biology and Therapy, vol.
, also known as deoxyribozyme, refers to a guanine-rich nucleic acid sequence with catalytic capabilities similar to common enzymes .
Zhou, "The sensitive and selective optical detection of mercury(II) ions by using a phosphorothioate DNAzyme
strategy," Chemistry--A European Journal, vol.
Using an Egr1 antisense oligodeoxy ribonucleotide or a catalytic deoxyribonucleic acid molecule (DNAzyme
) to inhibit Egr-1 has been shown to reduce myocardial inflammation and protect heart function against the I/R [11, 13].