DNAH.af.5

DNAH.af.5

A gene on chromosome 5p15.2 that encodes a dynein protein, which is part of a microtubule-associated motor-protein complex consisting of light, intermediate and heavy chains. DNAH5 is a heavy chain force-generating protein with ATPase activity; release of ADP produces the force-producing power stroke.

Molecular pathology
DNAH5 mutations cause primary ciliary dyskinesia type 3 and Kartagener syndrome.