DNA vaccine


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Related to DNA vaccine: recombinant vaccine, PubMed

DNA vaccine

a vaccine employing naked DNA from an organism to which immunity is intended to be conveyed; use remains in experimental stages..
Farlex Partner Medical Dictionary © Farlex 2012
A technique for protecting an organism against disease by injecting it with genetically engineered DNA to produce an immune response. This experimental vaccine carries a gene that encodes a protein responsible for an immune reaction against the pathogen of interest, which may be directly injected IM
Molecular medicine A vaccine in which a simple injection of a gene evokes the desired immune response to the protein encoded by the gene
Potential DNA vaccines Influenza, herpes, malaria, HIV, HPV, TB, chlamydia, hepatitis
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

DNA vaccine

an experimental VACCINE technology in which one or more genes encoding specific ANTIGENS are directly injected into the body, with a view to antigen production and stimulation of the IMMUNE RESPONSE. Such vaccines include several HIV genes. The technology would be useful for the production of inexpensive and heat-stable vaccines.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
This comprehensive report entitled Global DNA Vaccine Market Outlook 2022 provides an in-depth analysis of the global DNA Vaccines market, presenting readers a profound understanding of the various challenges, drivers, and developments in this industry.
has over 15 years of experience and is a provider of manufacturing and development services for DNA vaccines and gene therapies.
In this study, we investigated the enhancing influence of the fusion type CpG-SS on the effect of SS DNA vaccine. The efficiency of the novel SS DNA vaccine-fused CpG motifs in promoting the growth of ram lambs was evaluated by serum anti-SS antibody, GH and IGF-1 concentrations and average body weight.
This vaccine encodes an immunogen and a cytolytic protein (perforin), and has been shown to be significantly more immunogenic than a canonical DNA vaccine (which encodes an alternative immunogen) when delivered via the intradermal route.
Onate, "Immunogenicity of a multi-epitope DNA vaccine encoding epitopes from Cu-Zn superoxide dismutase and open reading frames of Brucella abortus in mice," Frontiers in Immunology, vol.
This is mainly because CTLA4-fused DNA vaccine can induce anti-CTLA-4 antibodies, thus avoiding competitive binding of B7 with CD28.
Fish DNA vaccine against infectious hematopoitic necrosis virus: efficacy of various routes of immunization.
By boosting the amount of proteins produced by the hosts' cells, this method might invoke a stronger immune response in patients receiving a DNA vaccine and, by making smaller vaccine doses possible, it also might reduce the risk that the patients immune system inadvertently would attack healthy host cells.
A number of features have to be kept in mind while designing a DNA vaccine. The selection of antigens, vector, delivery route, dose, timing, adjuvants, and boosting agents will all affect the outcome of vaccination.