DNA vaccine


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Related to DNA vaccine: recombinant vaccine, PubMed

DNA vaccine

a vaccine employing naked DNA from an organism to which immunity is intended to be conveyed; use remains in experimental stages..
A technique for protecting an organism against disease by injecting it with genetically engineered DNA to produce an immune response. This experimental vaccine carries a gene that encodes a protein responsible for an immune reaction against the pathogen of interest, which may be directly injected IM
Molecular medicine A vaccine in which a simple injection of a gene evokes the desired immune response to the protein encoded by the gene
Potential DNA vaccines Influenza, herpes, malaria, HIV, HPV, TB, chlamydia, hepatitis

DNA vaccine

an experimental VACCINE technology in which one or more genes encoding specific ANTIGENS are directly injected into the body, with a view to antigen production and stimulation of the IMMUNE RESPONSE. Such vaccines include several HIV genes. The technology would be useful for the production of inexpensive and heat-stable vaccines.
References in periodicals archive ?
This comprehensive report entitled Global DNA Vaccine Market Outlook 2022 provides an in-depth analysis of the global DNA Vaccines market, presenting readers a profound understanding of the various challenges, drivers, and developments in this industry.
has over 15 years of experience and is a provider of manufacturing and development services for DNA vaccines and gene therapies.
In this study, we investigated the enhancing influence of the fusion type CpG-SS on the effect of SS DNA vaccine. The efficiency of the novel SS DNA vaccine-fused CpG motifs in promoting the growth of ram lambs was evaluated by serum anti-SS antibody, GH and IGF-1 concentrations and average body weight.
This vaccine encodes an immunogen and a cytolytic protein (perforin), and has been shown to be significantly more immunogenic than a canonical DNA vaccine (which encodes an alternative immunogen) when delivered via the intradermal route.
Onate, "Immunogenicity of a multi-epitope DNA vaccine encoding epitopes from Cu-Zn superoxide dismutase and open reading frames of Brucella abortus in mice," Frontiers in Immunology, vol.
This is mainly because CTLA4-fused DNA vaccine can induce anti-CTLA-4 antibodies, thus avoiding competitive binding of B7 with CD28.
Fish DNA vaccine against infectious hematopoitic necrosis virus: efficacy of various routes of immunization.
By boosting the amount of proteins produced by the hosts' cells, this method might invoke a stronger immune response in patients receiving a DNA vaccine and, by making smaller vaccine doses possible, it also might reduce the risk that the patients immune system inadvertently would attack healthy host cells.
A number of features have to be kept in mind while designing a DNA vaccine. The selection of antigens, vector, delivery route, dose, timing, adjuvants, and boosting agents will all affect the outcome of vaccination.