topoisomerase

(redirected from DNA topoisomerase)
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Related to DNA topoisomerase: DNA gyrase

topoisomerase

 [to″po-i´so-mer-ās]
an enzyme involved in mobilization and replication of DNA during cell division.

to·po·i·so·mer·ase

(tō'pō-i-som'ĕr-ās),
A type of enzyme converting (isomerizing) one topologic version of DNA into another; acts by catalyzing the breakage and reformation of DNA phosphodiester linkages.
[topo- + isomerase]

topoisomerase

(tō′pō-ī-sŏm′ə-rās′, -rāz′)
n.
Either of two isomerase enzymes that alter the topology of DNA molecules by breaking and reconnecting coiled strands.
References in periodicals archive ?
Gorbsky, "Both alpha and beta isoforms of mammalian DNA topoisomerase II associate with chromosomes in mitosis," Cell Growth & Differentiation: The Molecular Biology Journal of the American Association for Cancer Research American Association for Cancer Research, vol.
Darzynkiewicz, "ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis," Cell Proliferation, vol.
Yoshida, "Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation," International Journal of Oncology, vol.
After damage of target molecules (DNA, microtubules, DNA topoisomerases etc.), they regulate DNA repair, cell cycle arrest, proliferation and apoptosis and thereby ultimately influence the fate of tumor cells on death or survival, even if the actual treatment targets are damaged.
Docking results revealed that DMIIMBP and DMIIMCP ligands are involved in hydrogen bonding and van der Waals interactions with the active site residues of DNA topoisomerase I.
Several investigations have proved that DNA-damaging agents such as DNA topoisomerase I and II inhibitors, alkylating compounds, or irradiation could trigger the inhibition of p34cdc2 kinase activity.
DNA sequence analysis of DNA gyrase and DNA topoisomerase IV quinolone resistance determining regions of Salmonella enterica serovar Typhi and serovar Paratyphi A.
Detection of the pine wood nematode using a real-time PCR assay to target the DNA topoisomerase I gene.
In order to determine the sequence of DNA products from PCR, blunt end ligation with a DNA topoisomerase provides an efficient way to clone the DNA into a vector [22].
We used primers designed to anneal to gene regions conserved in different poxviruses: FP-A2L, 5'-TAGTTTCAGAACAAGGATA TG-3' and RP-A2L, 5'-TTCCCATAT TAATTGATTACT-3' directed the amplification of a 482-bp fragment of the virus late transcription factor-3 (www.poxvirus.org); primer sets for the DNA polymerase gene (543-bp fragment) and DNA topoisomerase gene (344-bp fragment) were previously described (7).