DNA topoisomerase


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Related to DNA topoisomerase: DNA gyrase

DNA topoisomerase

/DNA topo·isom·er·ase/ (to″po-i-som´er-ās) either of two types of isomerase that catalyze the breakage, passage, and rejoining of one or both DNA strands, type I topoisomerases specific for single-strand passage and type II for double; thus altering the topology of the molecule.
References in periodicals archive ?
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.
There are many mechanism of action of these drugs, as inhibition of microtubule, inhibition of DNA topoisomerase II or DNA topoisomerase 1 inhibition (Cragg and Newman, 2005).
A nested PCR assay targeting the DNA topoisomerase I gene to detect the pine wood nematode, Bursaphelenchus xylophilus.
The nucleotide sequences obtained for the fragments of the DNA polymerase, DNA topoisomerase, and virus late transcription factor-3 of the clinical specimens were aligned with sequences from other poxviruses available in the public database (GenBank).
12] against the RS322N strain (835 [+ or -] 4[micro]g/mL) rather than to RS321 strain (1 306 [+ or -] 3 [micro]g/mL), this implies that this plant extracts showed moderate DNA topoisomerase I inhibitory activity; the other plant extracts did not show any DNA topoisomerase I or II inhibitory activity at all.
PCR-based identification of common dermatophyte species using primer sets specific for the DNA topoisomerase II genes.
6 October 2010 - US-based biopharmaceutical company Enzon Pharmaceuticals Inc (NASDAQ: ENZN) announced yesterday the publication of preclinical data demonstrating that PEG-SN38 (EZN-2208), the company's novel PEGylated DNA topoisomerase I inhibitor, led to significantly greater tumor regression as compared to CPT-11 (irinotecan) in both in vitro and in vivo models of pediatric neuroblastoma.
10) Utilizing advanced molecular technology, the research team that conducted these studies evaluated possible inhibitory effects of grape cell culture extract and subfractions on human DNA topoisomerase II catalytic activity.
8:40 ASSESSING DNA TOPOISOMERASE BINDING IN THE MYELOID-LYMPOID
Fluorescence spectroscopy studies of vaccinia type IB DNA topoisomerase.
The flavonoids fight an enzyme - known as human DNA topoisomerase II - that is crucial to the spread of cancer cells.