Gorbsky, "Both alpha and beta isoforms of mammalian DNA topoisomerase
II associate with chromosomes in mitosis," Cell Growth & Differentiation: The Molecular Biology Journal of the American Association for Cancer Research American Association for Cancer Research, vol.
Darzynkiewicz, "ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase
I inhibitor topotecan and during apoptosis," Cell Proliferation, vol.
Yoshida, "Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase
II activity and cancer cell proliferation," International Journal of Oncology, vol.
After damage of target molecules (DNA, microtubules, DNA topoisomerases
etc.), they regulate DNA repair, cell cycle arrest, proliferation and apoptosis and thereby ultimately influence the fate of tumor cells on death or survival, even if the actual treatment targets are damaged.
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase
The most significant locus is the QRDR in parC of DNA topoisomerase
IV [7, 29].
Docking results revealed that DMIIMBP and DMIIMCP ligands are involved in hydrogen bonding and van der Waals interactions with the active site residues of DNA topoisomerase
Several investigations have proved that DNA-damaging agents such as DNA topoisomerase
I and II inhibitors, alkylating compounds, or irradiation could trigger the inhibition of p34cdc2 kinase activity.
DNA sequence analysis of DNA gyrase and DNA topoisomerase
IV quinolone resistance determining regions of Salmonella enterica serovar Typhi and serovar Paratyphi A.
Detection of the pine wood nematode using a real-time PCR assay to target the DNA topoisomerase
In order to determine the sequence of DNA products from PCR, blunt end ligation with a DNA topoisomerase
provides an efficient way to clone the DNA into a vector .
We used primers designed to anneal to gene regions conserved in different poxviruses: FP-A2L, 5'-TAGTTTCAGAACAAGGATA TG-3' and RP-A2L, 5'-TTCCCATAT TAATTGATTACT-3' directed the amplification of a 482-bp fragment of the virus late transcription factor-3 (www.poxvirus.org); primer sets for the DNA polymerase gene (543-bp fragment) and DNA topoisomerase
gene (344-bp fragment) were previously described (7).