DNA repair enzyme

DNA repair enzyme

(1) DNA ligase (ATP), EC 6.5.1.1.
(2) DNA ligase (NAD+), EC 6.5.1.1.
References in periodicals archive ?
of Gladstone Institute of Neurological Disease, San Francisco, and her colleagues found low levels of BRCA1 protein, a DNA repair enzyme, in the brains of deceased Alzheimer's and mild cognitive impairment patients, compared with controls, as well as in mouse models of Alzheimer's.
A new approach to photoprotection is to repair DNA damage after UV exposure by delivering a DNA repair enzyme into the skin by means of specially engineered liposomes.
For many years, scientists have known that viruses rely on functions provided by their host cells to increase their numbers, but the UCI study - led by microbiology and molecular genetics professor Bert Semler - is the first to identify how the RNA-containing picornaviruses utilize a DNA repair enzyme to do so.
These results are similar to data obtained with the DNA repair enzyme Ogg1 and indicate the dependence of inhibition on the presence of free metal ions in solution (Zharkov and Rosenquist 2002).
com)-- In real life, the discovery of telomerase, the DNA repair enzyme for all plants and animals, was awarded the 2009 Nobel Prize in Medicine.
coli DNA repair enzyme, MutM, has been shown to remove 7,8-dihydro-8-oxoguanine (8-oxoG), an oxidatively damaged form of guanine nucleotide.
Two phase II trials of gefitinib are underway in patients with squamous cell carcinoma and topical therapies on the horizon include T4 endonuclease V, a bacterial DNA repair enzyme that increases the rate of repair of sunlight-induced DNA damage in human cells, Dr.
Several SNPs and somatic mutations have been characterized in a human 8-hydroxyguanine glycosylase gene, OGG1, which codes for a DNA repair enzyme responsible for excising 8-hydroxyguanine from damaged DNA (1, 2).
has announced that the National Cancer Institute intends to conduct a one-year clinical trial of its Dimericine, a topical liposomal DNA repair enzyme, to reduce the rate of skin cancer in renal transplant patients.
Also, a DNA repair enzyme derived from bacteria, T4 endonuclease V showed promise in an older study of 30 patients with xeroderma pigmentosum (Lancet.
VAL-083's mechanism of action is unaffected by the expression of MGMT, a DNA repair enzyme that causes chemotherapy resistance to front-line treatment with Temodar (temozolomide).