This was attributed to the effect of exercise on DNA repair enzyme
upregulation or related to the level of training.
Elsa Suberbielle, D.VM., Ph.D., of Gladstone Institute of Neurological Disease, San Francisco, and her colleagues found low levels of BRCA1 protein, a DNA repair enzyme
, in the brains of deceased Alzheimer's and mild cognitive impairment patients, compared with controls, as well as in mouse models of Alzheimer's.
Tainer, "Novel DNA binding motifs in the DNA repair enzyme
endonuclease III crystal structure," The EMBO Journal, vol.
A new approach to photoprotection is to repair DNA damage after UV exposure by delivering a DNA repair enzyme
into the skin by means of specially engineered liposomes.14 T4 endonuclease V has been shown to repair cyclobutane pyrimidine dimers resulting from DNA damage.15
For many years, scientists have known that viruses rely on functions provided by their host cells to increase their numbers, but the UCI study - led by microbiology and molecular genetics professor Bert Semler - is the first to identify how the RNA-containing picornaviruses utilize a DNA repair enzyme
to do so.
The human OGG1 DNA repair enzyme
and its association with orolaryngeal cancer risk.
Moreover, exposure of lung alveolar epithelial cells to Cd has been shown to significantly reduce the activity of the DNA repair enzyme
formamido-pyrimidine DNA glycosylase (Potts et al.
Santa Ana, CA, April 29, 2010 --(PR.com)-- In real life, the discovery of telomerase, the DNA repair enzyme
for all plants and animals, was awarded the 2009 Nobel Prize in Medicine.
coli DNA repair enzyme
, MutM, has been shown to remove 7,8-dihydro-8-oxoguanine (8-oxoG), an oxidatively damaged form of guanine nucleotide.
Several SNPs and somatic mutations have been characterized in a human 8-hydroxyguanine glycosylase gene, OGG1, which codes for a DNA repair enzyme
responsible for excising 8-hydroxyguanine from damaged DNA (1, 2).
Another agent in clinical development that may have a "field effect" in treating AKs is T4 endonuclease V, a DNA repair enzyme
that may also restore p53 gene function.
Dermatics (AGI), Freeport, N.Y., has announced that the National Cancer Institute intends to conduct a one-year clinical trial of its Dimericine, a topical liposomal DNA repair enzyme
, to reduce the rate of skin cancer in renal transplant patients.