DNMT1

(redirected from DNA methyltransferase 1)

DNMT1

A gene on chromosome 19q13.2 that encodes a DNA (cytosine-5-)-methyltransferase 1, which methylates CpG residues and plays a critical role in establishing and regulating tissue-specific patterns of cytosine methylation.

Molecular pathology
Aberrant methylation patterns are associated with certain human tumours (e.g., breast carcinoma) and developmental
abnormalities.
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References in periodicals archive ?
Primary antibodies against DNA methyltransferase 1 (DNMT1; catalogue number: 5032, 1 : 1000 dilution), vimentin (catalogue number: 5741, 1: 1000 dilution), [beta]-catenin (catalogue number: 8480, 1:1000 dilution), and [p21.sup.waf1/cip] (catalogue number: 2947, 1 : 1000 dilution) were purchased from Cell Signaling Technology (Danvers, MA, USA); p53 (catalogue number: ab131442, 0.02 [micro]g/mL dilution) from Abcam (Cambridge, UK); p16 (catalogue number: sc-759; 1:500 dilution) from Santa Cruz Biotechnology (Dallas, TX, USA); and Tet methylcytosine dioxygenase 1 (TET1; catalogue number: NBP2-15135; 1:1000 dilution) and deoxycytidine kinase (dCK; catalogue number: H00001633-B01P; 1 [micro]g/mL dilution) from Novus Biologicals (Littleton, CO, USA).
Liang et al., "MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1," Arthritis and Rheumatism, vol.
[15] DNMT1 DNA methyltransferase 1 [Homo sapiens (human)].
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
(2009) screened yeast deletion mutants to identify genes required for the growth of yeast in the presence of MMAIII and iAsIII and found that an S-adenosylmethionine-dependent methyltransferase, corresponding to the putative N-6-adenine-specific DNA methyltransferase 1 (N6AMT1) in humans, conferred resistance to these arsenic species.
De novo DNA methyltransferases are enzymes evolved on the establishment of DNA methylation pattern during the earlier stages of embriogenesis because, differently of DNMT1 (DNA methyltransferase 1), they need not a hemimethylated DNA to establish the existent human genome methylation pattern (Okano, Xie & Li, 1998; Okano et al., 1999; Siedlecki et al., 2003).
Yen et al., "Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells," Genome Research, vol.
Kyung, "Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway," Cancer Research, vol.
771) investigated the potential role of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic-induced toxicity.
We systematically searched the PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure databases using different combinations of the search terms "DNMT1 or DNA methyltransferase 1," "polymorphism or mutation or variant," and "cancer or neoplasm ort umor." The search was last updated on 06 June 2016.
The human ortholog of the yeast MTQ2 is N-6 adenine-specific DNA methyltransferase 1 (N6AMT1), encoding a putative methyltransferase.