DNA methyltransferase

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DNA methyltransferase

An enzyme that adds methyl groups to DNA (nucleic acids) so as to modify gene expression.

Types of DNA methyltransferase
• DNMT1—Responsible for hemimethylated CpG island methylation.
• TRDMT1 (formerly DNMT2, renamed tRNA aspartic acid methyltransferase 1)—Transfers methyl groups to RNA.
• DNMT3—Responsible for unmethylated CpG island methylation.

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References in periodicals archive ?

Methylation of O6-Methylguanine DNA Methyltransferase and Loss of Heterozygosity on 19q and/or 17p are Overlapping Features of Secondary Glioblastomas with Prolonged Survival.

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Subsequently, such a de novo methylation events are maintained during DNA replication by DNA methyltransferase Dnmt1 [13].

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These lncRNAs, can emanate in trans from pseudogenes or cis, and antisense to their protein-coding counterparts, and guide epigenetic remodeling complexes consisting of Enhancer of Zeste (Ezh2) and DNA methyltransferase 3a (DNMT3a) to target loci.

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Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.

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The behavioral changes in females corresponded to changes in activity of a specific DNA methyltransferase called Dnmt3a.

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Further studies are required to understand the mechanisms by which ROS interact with antioxidant enzymes regulation, likely involving the dual DNA methyltransferase and histone-modifying enzymes [25].

Age-Dependent Demethylation of Sod2 Promoter in the Mouse Femoral Artery

The process of DNA methylation is catalyzed by a group of enzymes known as DNA methyltransferases (DNMTs), the most well-studied of which is the major maintenance DNA methyltransferase DNMT1.

Epigenetic Mechanisms of Human Papillomavirus-Associated Head and Neck Cancer

CpG sites are regions of DNA wherein a cytosine nucleotide becomes methylated through DNA methyltransferase enzymes which have the net effect of suppressing gene transcription.

Epigenetics: nature meets nurture in psychiatry

Researchers found that theaflavin-3 (TF-3), the antioxidant, works by inhibiting the function of an enzyme called DNA methyltransferase, which destroys bone tissue.

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Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons.

Epigenetic drugs: a hope to treat cancer

Researchers found that theaflavin3 (TF3), the antioxidant, works by inhibiting the function of an enzyme called DNA methyltransferase, which destroys bone tissue.