It is reasonable to suggest that DNA methyltransferase
inhibitors, by decreasing DNA methylation on the SOD2 gene locus and consequently favoring the SOD2 gene and protein expression, may be able to alleviate PASMCs proliferation and consequently SOD2 down-regulation in PAH.
The DNMT3B DNA methyltransferase
gene is mutated in the ICF immunodeficiency syndrome.
inhibitors for cancer therapy.
DNA methylation is one of the most important epigenetic changes; it is catalyzed by DNA methyltransferase
(DNMT) enzymes and takes place with the help of proteins that bind methyl-CpG (MBD1, MBD2, MeCP2, etc.).
Lowered DNA methyltransferase
(DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism.
Maggert et al., "Methylation of [tRNA.sup.Asp] by the DNA methyltransferase
homolog Dnmt2," Science, vol.
The incorporation of azacytidine into RNA or decitabine into DNA triggers two main antitumor cellular activities through the induction of cytotoxicity leading to DNA damage response and DNA hypomethylation through inhibition of DNA methyltransferase
which enables reactivation of tumor suppressor genes for normal growth and differentiation.
5-Azacytidine blocks the active site of DNA methyltransferase
enzymes which confer methylation patterns to the novel strand during DNA replication, inhibiting the methylation transferral process .
Yang et al., "TGF[beta]-incurred epigenetic aberrations of miRNA and DNA methyltransferase
suppress klotho and potentiate renal fibrosis," Biochimica et Biophysica Acta (BBA)--Molecular Cell Research, vol.
Chinese herbal medicine Xiaoji decoction inhibited growth of lung cancer cells through AMPK[alpha]-mediated inhibition of Sp1 and DNA methyltransferase
(37,38) We showed that, in spite of the presence of LIF-induced activated STAT3 (LIF is usually supplemented in the embryonic stem cell (ESC) maintenance medium), both wild type ESCs and ESCs deficient for all DNA methyltransferase
genes (Dnmt1, Dnmt3a, and Dnmt3b) (Dnmt-TKO ESCs) failed to express Gfap, although the Gfap promoter of Dnmt-TKO ESCs was almost completely demethylated (Fig.
The involvement of HBV infection in epigenetic alternations during hepatocarcinogenesis has been described; HBV X (HBx) protein expression promoted DNA methyltransferase
(DNMT) activity by upregulation of DNMT1, DNMT3A1, and DNMT3A2 and selectively facilitated regional hypermethylation of specific tumor suppressor genes .