DNA methylation


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DNA methylation

n.
The modification of a DNA base by the addition of a methyl group (CH3). DNA methylation of cytosines in particular regions of a gene can cause that gene's suppression.

DNA methylation

The addition of a methyl group to the cytosine ring that occurs in DNA when it is replicated in a dividing cell. The process forms methyl cytosine and is catalysed by enzymes called DNA methyltransferases. In humans, the change occurs only to those cytosines that preceded guanines in the DNA sequence. Methyl cytosine has a strong tendency to deaminate to form thymidine, and if this mutation is not repaired it remains. It is the commonest kind of genetic variation (polymorphism) in human populations.
References in periodicals archive ?
This reliable, clinically validated assay determines the PITX2 DNA methylation ratio to differentiate between patients who are more likely or less likely to show beneficial response to anthracyclines, said Thierry Bernard, Senior Vice President, Molecular Diagnostics Business Area, for QIAGEN.
In this study, we aimed to survey the genome-wide DNA methylation pattern in the longissimus dorsi muscle (LDM) to identify methylated genes which contributed to the differences in growth and carcass traits between Small Tailed Han and Dorperx-Small Tailed Han crossbred sheep.
DNA methylation is an essential component of epigenetics and plays a critical role in many biological events.
when the epigenetic signature of DNA methylation was observed to
The DNA methylation markers are potentially linked to phenotypic variations, especially in closely related strains (Takata et al.
Lifetime exposure to stress has been convincingly shown to accelerate epigenetic aging, as reflected by DNA methylation level.
Many studies have highlighted the relevance of DNA methylation in developmental processes (Fang and Chao, 2007).
They added that this study is the largest one examining the effects of smoking on DNA methylation.
The researchers do not yet understand the connection between tumors and elevated DNA methylation.
DNA methylation is a physical modification to the genetic material (DNA) of a cell, which can alter the behavior of that cell.
In addition to DNA methylation, femoral arteries were also used, in the same mice, to assess endothelial function in isolated pressurized segments, further limiting the amount of tissue available.