genetic marker(redirected from DNA marker)
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1. pertaining to reproduction or to birth or origin.
genetic code the arrangement of nucleotides in the polynucleotide chain of a chromosome; it governs the transmission of genetic information to proteins, i.e., determines the sequence of amino acids in the polypeptide chain making up each protein synthesized by the cell. Genetic information is coded in DNA by means of four bases: two purines (adenine and guanine) and two pyrimidines (thymine and cystosine). Each adjacent sequence of three bases (a codon) determines the insertion of a specific amino acid. In RNA, uracil replaces thymine.
1. the location of mutations along the length of a chromosome, as determined by recombination experiments. The unit of length is the centimorgan (cM), one crossover per meiosis.
2. the sequence of base pairs along the DNA of a chromosome, a technique being applied to humans.
genetic marker a gene having alleles that are all expressed in the phenotype, that is, they are codominant, and which can be used to study inheritance. The various blood group systems and serum or red blood cell proteins easily detected by electrophoresis or immunodiffusion are commonly used markers.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
any antigenic determinant or identifying characteristic, particularly those of allotypes.
Synonym(s): genetic marker
Farlex Partner Medical Dictionary © Farlex 2012
A gene, DNA sequence, or gene product whose inheritance can be traced through a pedigree or phylogeny. Genetic markers are used in paternity testing, studies of evolution, and evaluating genetic contributions to phenotypes including disease. Genetic markers associated with certain diseases can often be detected in the blood serum, where their presence is used to determine whether a person is at high risk for developing a disease.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
ge·net·ic de·ter·mi·nant(jĕ-net'ik dĕ-tĕr'mi-nănt)
Any antigenic determinant or identifying characteristic, particularly those of allotypes.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
genetic markerA gene or DNA sequence that indicates the presence of a disease or a probable risk of developing it.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
- a phenotypic character that can be assigned to a GENE to mark its position on the GENOME.
- a characteristic feature of the GENOTYPE, such as a NUCLEOTIDE signature, gene or HETEROCHROMATIC region, that can be used to track a particular individual, TISSUE, CELL, NUCLEUS, CHROMOSOME, PLASMID or gene. Genetic markers are used, for example, to detect the presence of cloning VECTORS in GENETIC ENGINEERING and to monitor ORGANISMS released into the environment. See RESTRICTION FRAGMENT LENGTH POLYMORPHISM.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005