DNA laddering


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DNA laddering

The fragmentation of DNA that occurs during apoptosis.
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Evaluation of apoptosis using DNA laddering: After 14 days of culture, the human ovarian tissues and apoptosis-induced tissues were assessed for DNA laddering (n=3 in each subgroup).
Those were used for DNA laddering assay and calculation of oxidative stress parameters.
Meanwhile, early and late apoptotic events via the Annexin V-FITC and DNA laddering assays, respectively.
Assessment of DNA damage in bone marrow mesenchymal stem cells following Imidazole treatment by fast halo assay and DNA laddering assay.
DNA laddering assay is a common method to detect apoptotic DNA fragmentation in cells.
Detection of DNA laddering in influenza virus infected HeLa cells: DNA laddering is commonly accepted as an important biochemical hallmark of apoptosis.
This study was undertaken to determine if internucleosomal DNA cleavage (DNA laddering) and caspase-dependent PCD occurs in apoptotic neurons.
Thus, although present in a small percentage of cells, DNA laddering from apoptotic cells was well below the detection limit of our biochemical method.
Apoptosis-related DNA laddering was visible after treatment of MCF-7 cells with increasing CSA concentrations for 48 h (Fig.
Apoptotic phenotypes including apoptotic body formation, DNA laddering, caspase 3 activation and cleavage of PARP proteins were induced by [CM.sub.FB] treatment but only slightly induced by same concentration of [CM.sub.MY] treatment in human HL-60 leukemia cells.
The occurrence of apoptosis mediated cell death was confirmed through the activation endonucleases-mediated nucleosome excision leading to the observation of DNA laddering of about 180-200 bp.