While this is occurring, DNA helicase
, SSBs, and (depending on the precise reaction mixture) some other accessory factors come in and unwind the new nascent strand from the original template.
Dynamic effects of cofactors and DNA on the oligomeric state of human mitochondrial DNA helicase
Under the license granted by Alnylam, GeneCare has exclusive rights to investigate RNAi therapeutics directed against two specific genes belonging to the RecQ DNA helicase
gene family that are believed to be relevant to the treatment of cancer and possibly other human diseases.
17 Cell, Bloom's syndrome results from mutations in the gene needed to produce an enzyme classified as a DNA helicase
In both cases, fluoroquinolones appear to trap the enzyme on DNA during the topoisomerization reaction, forming a physical barrier to the movement of the replication fork (4), RNA polymerase (5), and DNA helicase