DNA chip


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An array of DNA oligonucleotides synthesised in situ by photomasking on a semiconductor chip

DNA chip

a wafer of silicon (about 2cm2) carrying an orderly, high density array of OLIGONUCLEOTIDE PROBES (about 20 - 80 nucleotides), either synthesized in situ on the surface of the chip using, for example, laser lithography, or synthesized conventionally and then immobilized on the chip. Each probe is at a precisely defined location on the chip.

The basic procedure for using DNA chips is similar to that for DNA MICROARRAYS.

References in periodicals archive ?
Normalization or calibration steps are regularly performed in microarray data analysis to accurately adjust and correct the variability in intensity values extracted from two separate samples according to a standard set of control genes or against all the targets represented on the DNA chip. A final mean ratio pixel intensity value is calculated for each gene target and processed into a standard 24-bit pseudocolor composite image for visualization of the gene expression profile.
Although DNA chips encompassing fly genes will unleash a torrent of data, some scientists caution that the information won't make sense without years of follow-up research.
In all cases, DNA sequencing analysis was performed to determine the correct genotype, and in all cases the CF Portrait DNA Chip had assigned the correct genotype with the errors being assigned to the Apples OLA assay.
One of the most dramatic developments in DNA chip technology has been Affymetrix's continuing ability to reduce the size of the features where the DNA probes reside.
Further, Toray and DNA Chip Research will proceed with research with a view to developing DNA chips for diagnosis of diseases, especially cancer and life-style related diseases, within two years.
The readout of DNA chips involves detection of a reporter molecule, which typically is incorporated into the gene amplification product (Fig.
The developed DNA chip based on electrocopolymerization on gold electrodes gives a support with low autofluorescence, allowing the detection of <10% of mutated sequences within a mixed mutant/wild-type population.
The third type of DNA chip is the "lab-on-a-chip", microfluidic systems that perform all the steps of molecular genetic analysis on a chip.
If biotechnology is the hottest market in the analytical instruments industry, then DNA chip technologies have to be among the hottest of the hot.
Many of the problems may be solved in the future by the introduction of DNA chip technology, which makes possible the combined detection and identification of mutations.
obtained exclusive rights from Genetic MicroSystems to sell its DNA chip production and analysis systems in Japan, South Korea, China, and Taiwan, and it will begin marketing those products this month, with a set including production and analysis systems selling for e47 million ($343,000), according to Takara Shuzo officials...Molecular Dynamics received notice of early termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act, with regard to its pending acquisition by Amersham Pharmacia Biotech...EG&G President Greg Summe told the Boston Herald that EG&G was scouting for acquisition targets, according to Reuters.
The companies include Goring Kerr, Best Inspection, and Allen Coding...Perkin-Elmer and Hyseq announced that they will offer pharmaceutical research companies early access to their advanced DNA chip products...Varian completed its previously announced acquisition of Chrompack, manufacturer of chromatography equipment and consumables for an undisclosed amount...Chemunex, manufacturer of products for the rapid, ultrasensitive detection of microbial contaminants, is to be listed on the Bourse de Paris (France's stock exchange), according to the Chemical Business Newsbase...