DMSO


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DMSO

 
dimethyl sulfoxide, an industrial solvent that has the ability to penetrate plant and animal tissues and to preserve living cells during freezing. It has been used investigationally as an agent to increase the penetrability of other substances and as a topical analgesic and antiinflammatory. It has been approved by the U.S. Food and Drug Administration in a 50 per cent solution for direct instillation into the bladder for the treatment of interstitial cystitis. A 90 per cent solution, which has been approved only for veterinary use, is believed by some to be beneficial in the treatment of muscle sprains and strains, arthritis, spinal cord injuries, and the aftereffects of stroke when it is applied externally and absorbed by the skin. Claims that it is effective for treating these disorders in humans have not been validated by research studies. It has been shown to produce some short-term side effects.

DMSO

Abbreviation for dimethyl sulfoxide.

DMSO

(dē′ĕm-ĕs-ō′)
n.
A colorless hygroscopic liquid, (CH3)2SO, obtained from lignin, used as an industrial solvent and in medicine as a penetrant to convey medications into the tissues.

DMSO

Alternative medicine
A substance that occurs naturally in minute amounts in certain foods, which has industrial and health-related applications. Animal studies have shown it to have analgesic, anti-inflammatory, antimicrobial, vasodilatory and other properties; up to the 1960s, DMSO had been administered orally, topically or parenterally by mainstream physicians for various conditions, including arthritis, bursitis, cancer, emphysema, mental illness and pain. In the face of its association with lenticular degeneration, DMSO was removed from general use; some practitioners of alternative healthcare continue to recommend DMSO for these and other uses.
 
Toxicity
Topical DMSO is associated burning, itching and an unpleasant odour.
 
Mainstream medicine
DMSO is FDA-approved for treating interstitial cystitis, and may be of use in treating scleroderma, sprains, arthritis, cerebrovascular accidents, familial amyloidotic polyneuropathy and acetaminophen hepatotoxicity. DMSO reduces the ice crystals formed in frozen section tissues from the operating suite, and may be an effective cryopreservative.

DMSO

Abbreviation for dimethyl sulfoxide.

DMSO

Abbreviation for dimethyl sulfoxide.
References in periodicals archive ?
Also, PEDOT:PSS films (fabricated from PEDOT:PSS dispersion treated with DMSO) behaved like a metal only above ~350 K when deposited on poly(ethyleneterephthalate) (PET) non-woven microfibers [14] and over short temperature ranges far below 380 K when deposited on cotton fabrics [17].
When the effect of irrigant regardless of the sealer was analyzed, saline had the highest immediate leakage rate that was significantly higher than that with DMSO (p=0.032; Mann-Whitney test).
Further justification of this assumption is provided by control experiments from UV studies of the receptor containing one equivalent of hydroxide or fluoride in DMSO (Figure 8).
After 24 hours of filtration, fibres were sectioned for confocal microscopy, and more MNCs were observed within DMSO fibres in comparison with water fibres.
Pyrene solvation in DMSO apparently leads to more efficient concentrating of the probe on the hydrophobic CDA matrix [22, 23].
In this study, hemicelluloses from Neosinocalamus affinis were extracted by DMSO and 3% NaOH, sequentially precipitated by ethanol with gradient concentration.
(2013), who compared the slow freezing of testicular tissue of adult cats (Felis silvestres catus) with cryopreservation using DMSO, ethylene glycol, glycerol, and propanediol.
Relative gene expressions were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and mRNA expression levels were presented as fold changes versus DMSO group.
Mature oocytes obtained from 8-week-old B6D2F1 mice were vitrified in a solution consisting various concentration of L-proline with a reduced proportion of dimethyl sulfoxide (DMSO) and ethylene glycol (EG), comparing with the control group (15% DMSO and 15% EG without L-proline).