Disease-modifying anti-rheumatic drugs, drugs used mainly in the treatment of RHEUMATOID ARTHRITIS. They act in various ways to relieve the severity of the condition.

Disease Modifying Anti-Rheumatic Drugs (DMARDs)

A class of antirheumatic drugs, including chloroquine, methotrexate, cyclosporine, and gold compounds, that influence the disease process itself and do not only treat its symptoms.
Mentioned in: Antirheumatic Drugs

disease-modifying antirheumatic drugs

; DMARDs group of cytokine-inhibiting agents, used singly or in combination, to minimize and/or control inflammation, joint swelling and tissue destruction characteristic of rheumatoid disease, reducing incidence of irreversible joint damage; e.g. penicillamine, gold salts, antimalarials (chloroquine and hydroxychloroquine), drugs affecting the immune response (azathioprine, methotrexate and enteracept), sulfasalazine and corticosteroids
References in periodicals archive ?
Other biologic DMARDs, including IL-1 and IL-6 inhibitors, are also used, and combination therapy with multiple biologic and nonbiologic DMARDs is necessary in some patients.
3 [+ or -] 8 years and treated with DMARDs at the Military Institute of Medicine outpatient clinic between January 01, 2010--December 31 2010 were included in the study.
In unadjusted analyses, women taking both steroids and DMARDs had significantly higher odds of preterm birth relative to peers who took neither (relative risk, 2.
14) Furthermore, there is limited evidence discussing the infection risk for patients, treated with anti TNF[alpha] therapy, after orthopaedic procedures, with no studies examining the change in risk for late onset PJI for patients started on TNF[alpha] DMARDs.
More than 75 per cent of patients were previously treated with Dmards only and 22 per cent of patients were previously treated with biologics.
5-7] Thus, early diagnosis and prompt referral to a physician, or ideally to a rheumatologist, for initiation of DMARDs is critical.
Potential subjects who have previously used DMARDs, may be eligible to participate provided the following washout periods are met:
They can have side effects, but there are several DMARDs and some people try a few before finding a combination that suits them best.
A retrospective cohort study of 20,357 RA patients in the Veterans Affairs health care system found that patients on adalimumab had an adjusted 47% lower risk of zoster, and those on etanercept had a 38% reduction in risk, compared with patients on conventional DMARDs.
DMARDs (Disease Modifying Anti-Rheumatic Drugs) are a category of drugs defined by their use in rheumatoid arthritis to slow disease progression.
Encouragingly, treatment with DMARDs decreased the risk but COX-2 inhibitors appeared to predict a new event.
Synthetic DMARDs - there is strong evidence that early treatment with synthetic DMARDs retards radiographic progression, and therefore DMARD therapy early inflammatory arthritis before the stage of fulfilling ACR criteria for RA, treating with DMARDs (MTX) reduces progression of radiogaphic damage.