DLK1


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DLK1

A gene on chromosome 14q32 that encodes a transmembrane protein  and putative tumour suppressor that plays a role in the differentiation of various cell types, including adipocytes and neuroendocrine cells.
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"By uncovering both the new stem cells that make the main body of a tooth and establishing their vital use of Dlk1 in regenerating the tissue, we have taken major steps in understanding stem cell regeneration," Hu said.A
When these stem cells are activated, they then send signals back to the mother cells of the tissue to control the number of cells produced, through a molecular gene called Dlk1.
The short isoform of IGF2BP2, p62, is overexpressed in HCC with stem-like features and hypervascularization, and the livers of p62 transgenic mice highly express the stem cell marker DLK1 and generate tumors with more aggressive and stemlike phenotype [27].
Wei et al., "MicroRNA-1265p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1," Nature Medicine, vol.
(2001) Human--Ovine Comparative Sequencing of a 250-kb Imprinted Domain Encompassing the Callipyge (clpg) Locus and Identification of Six Imprinted Transcripts: DLK1, DAT, GTL2, PEGU, antiPEGll, and MEG8.
A range of MAP3Ks have been implicated in the activation of the p38 MAPK pathway, including MLKs (mixed-lineage kinases), TAK1 (transforming growth factor [beta] activated kinase 1), ASK1 (apoptosis signal-regulating kinase 1), TAO (thousand-and-one amino acid), DLK1 (dual-leucine-zipper-bearing kinase 1) MEKKs, and ZAK1 (leucine zipper and sterile-[alpha] motif kinase 1) (Figure 1).
Expressions of Smad3, Smad6, Smad9, MEG, and DLK1 were significantly decreased in NFA.
Expression levels of delta-like 1 homolog (DLK1) (a marker for preadipocytes) measured on all time points of differentiation and maintenance indicated no dedifferentiation to preadipocytes.
Satellite cell heterogeneity with respect to expression of MyoD, myogenin, Dlk1 and c-Met in human skeletal muscle: application to a cohort of power lifters and sedentary men.
Effect of DLK1 and RTL1 but not MEG3 orMEG8 on muscle gene expression in callipyge lambs.
(119) More recently, in 2013, they also showed that Dlk1 ([delta]-like homologue 1 and also named Pref-1: preadipocyte factor-1 (120)), an inhibitor of adipocyte differentiation, is co-expressed with Shh in zU of the rat adrenal gland.121)