A gene on chromosome 14q32 that encodes a transmembrane protein and putative tumour suppressor that plays a role in the differentiation of various cell types, including adipocytes and neuroendocrine cells.
"By uncovering both the new stem cells that make the main body of a tooth and establishing their vital use of Dlk1 in regenerating the tissue, we have taken major steps in understanding stem cell regeneration," Hu said.A
The short isoform of IGF2BP2, p62, is overexpressed in HCC with stem-like features and hypervascularization, and the livers of p62 transgenic mice highly express the stem cell marker DLK1 and generate tumors with more aggressive and stemlike phenotype .
(2001) Human--Ovine Comparative Sequencing of a 250-kb Imprinted Domain Encompassing the Callipyge (clpg) Locus and Identification of Six Imprinted Transcripts: DLK1, DAT, GTL2, PEGU, antiPEGll, and MEG8.
A range of MAP3Ks have been implicated in the activation of the p38 MAPK pathway, including MLKs (mixed-lineage kinases), TAK1 (transforming growth factor [beta] activated kinase 1), ASK1 (apoptosis signal-regulating kinase 1), TAO (thousand-and-one amino acid), DLK1 (dual-leucine-zipper-bearing kinase 1) MEKKs, and ZAK1 (leucine zipper and sterile-[alpha] motif kinase 1) (Figure 1).
(119) More recently, in 2013, they also showed that Dlk1 ([delta]-like homologue 1 and also named Pref-1: preadipocyte factor-1 (120)), an inhibitor of adipocyte differentiation, is co-expressed with Shh in zU of the rat adrenal gland.121)