DLK1

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DLK1

A gene on chromosome 14q32 that encodes a transmembrane protein  and putative tumour suppressor that plays a role in the differentiation of various cell types, including adipocytes and neuroendocrine cells.
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elegans p38 MAPK pathway, consisting of DLK-1 (a DLK-type MAPKKK), MKK-4 (a MLK4-type MAPKK) and PMK-3 (a p38-type MAPK), regulates presynaptic development.
Several studies have demonstrated that the homologues of DLK-1 are required for axon regeneration in both Drosophila melanogaster and mice.
45) DLK-1 p38 MAPK signaling promotes axon regeneration by activating the MAPKAP kinase MAK-2, which functions to stabilize the mRNA encoding the bZip transcription factor CEBP-1.
For example, DLK-1 and MLK-1 are both targeted for ubiquitin-mediated degradation by the E3 ubiquitin ligase RPM-1.
The downstream effector of DLK-1 p38 MAPK signaling in axon regeneration is the MAPK-activated kinase 2 MAK-2, which regulates stability of the cebp-1 mRNA encoding a bZip family transcription factor.
60)-63) Recently it was demonstrated that one major role of DLK-1 signaling in axon regeneration is the control of microtubule dynamics via the kinesin-13 family member KLP-7 and the microtubule-modifying enzyme cytosolic carboxypeptidase CCPP-6.
2009) The DLK-1 kinase promotes mRNA stability and local translation in C.