DLG4

DLG4

A gene on chromosome 17p13.1 that encodes a member of the membrane-associated guanylate kinase (MAGUK) family that forms a complex with another MAGUK, DLG2, and is recruited into NMDA receptor and potassium channel clusters. DLG2 and DLG4 may interact at postsynaptic sites to form a multimeric scaffold for clustering of receptors, ion channels and signalling proteins.
References in periodicals archive ?
It was found that expression of TP53 (HR 1.9, p = 31 x [10.sup.-7]) was associated with worse overall survival (OS) for glioma patients, as well as TOP2A (HR 4.4, p = 0), CDK1 (HR 4.8, p = 0), CCNB1 (HR 5.9, p = 0), CDC20 (HR 5.2, p = 0), CCNA2 (HR 5.1, p = 0), NDC80 (HR 5.8, p = 0), AURKA (HR 5.3, p = 0), BIRC5 (HR 5, p = 0), CCNB2 (HR 5.4, p = 0), KIF11 (HR 2.3, p = 15 x [10.sup.-10]), and MAD2L1 (HR 4.4, p = 0), while expression of PHLPP2 (HR 0.41, p = 1.3x [10.sup.-11]), DLG4 (HR 0.59, p = 35 x [10.sup.-5]), and MYC (HR 0.58, p = 2.1 x [10.sup.-5]) was associated with better overall survival (OS) for glioma patients (Figure 3).
Of these 15 hub genes, PHLPP2, DLG4, and MYC displayed significant positive correlation with overall survival while TP53, TOP2A, CDK1, CCNB1, CDC20, CCNA2, NDC80, AURKA, BIRC5, CCNB2, KIF11, and MAD2L1 negatively correlated with overall survival in patients with glioma.
Caption: Figure 3: Prognostic value of 15 genes (TP53, TOP2A, CDK1, PHLPP2, DLG4, CCNB1, MYC, CDC20, CCNA2, NDC80, AURKA, BIRC5, CCNB2, KIF11, and MAD2L1) in glioma patients.
(b) Expression level of DLG4 in cancer and normal tissues; * p < 0.05.
The postsynaptic density protein 95 (PSD-95; also known as DLG4 and SAP90) is the most abundant protein in excitatory chemical synapses and the main scaffolding protein at the PSD.
Mathur et al., "Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome," The American Journal of Psychiatry, vol.
They apply their methods to find answers and explanations to some complex queries related to drug discovery (for example, "What are the genes that are targeted by the drug Epinephrine and that interact with the gene DLG4?", "What are the genes related to the gene ADRB1 through a gene-gene relation chain of length at most three?" and "What are the most similar three genes that are targeted by the drug Epinephrine?") over the biomedical knowledge resources PharmGKB, DrugBank, BioGRID, CTD, SIDER, and Disease Ontology.