DLG3 | definition of DLG3 by Medical dictionary
DLG3 A gene on chromosome Xq13.1 that encodes a member of the membrane-associated guanylate kinase (MAGUK) family thought to play a role in clustering of NMDA receptors at excitatory synapses; it may also downregulate cell proliferation by interacting with the C-terminal region of the adenomatosis polyposis coli tumour suppressor protein. DLG3 is also the retired HUGO symbol for what is now designated MPP3, see there.
DLG3 mutations are associated with X-linked mental retardation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
They found that miR-1246 was specifically up-regulated by EV71 in SH-SY5Y cells and could directly bound with the 3' UTR of disk-large homolog 3 (DLG3) gene, which is associated with neurological disorders.
Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repression.
miR-296-5p Repression of viral EV71 VP3 and 37 replication VP1-coding region miR-23b Repression of viral EV71 3' UTR 38 replication miR373 and Repression of viral EV71 5' UTR 39 miR542-5p replication miRNA-548 Enhancement of IFN-[lambda]1 41 replication of EV71 and VSV miR-146a Enhancement of viral IRAK1 and TRAF6 42 pathogenesis miR-526a Repression of viral CYLD 43 replication miR-146a and Enhancement of EV71- SOS1and 44 miR-370 induced cell apoptosis GADD45[beta] miR-141 Enhancement of EV eIF4E 45 propagation miR-27a Repression of viral EGFR 46 replication miR-1246 Contribution to the DLG3 47 neurological pathogenesis Table 2--MiRNAs involved in CVB3infection.