DLG3

DLG3

A gene on chromosome Xq13.1 that encodes a member of the membrane-associated guanylate kinase (MAGUK) family thought to play a role in clustering of NMDA receptors at excitatory synapses; it may also downregulate cell proliferation by interacting with the C-terminal region of the adenomatosis polyposis coli tumour suppressor protein. DLG3 is also the retired HUGO symbol for what is now designated MPP3, see there. 

Molecular pathology
DLG3 mutations are associated with X-linked mental retardation.
References in periodicals archive ?
Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repression.
miR-296-5p Repression of viral EV71 VP3 and 37 replication VP1-coding region miR-23b Repression of viral EV71 3' UTR 38 replication miR373 and Repression of viral EV71 5' UTR 39 miR542-5p replication miRNA-548 Enhancement of IFN-[lambda]1 41 replication of EV71 and VSV miR-146a Enhancement of viral IRAK1 and TRAF6 42 pathogenesis miR-526a Repression of viral CYLD 43 replication miR-146a and Enhancement of EV71- SOS1and 44 miR-370 induced cell apoptosis GADD45[beta] miR-141 Enhancement of EV eIF4E 45 propagation miR-27a Repression of viral EGFR 46 replication miR-1246 Contribution to the DLG3 47 neurological pathogenesis Table 2--MiRNAs involved in CVB3infection.