DLG2

DLG2

A gene on chromosome 14q14.1 that encodes a member of the membrane-associated guanylate kinase (MAGUK) family, which forms a heterodimer with related family members, interacting at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signalling proteins. DLG2 is also the retired HUGO symbol for what is now designated MPP2, see there.
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We analyzed the characteristics of the gene partners (see details in Supplementary Table 1) to potentially define the molecular functions of the identified fusions, and we observed that chromatin modifiers (KMTA2-MLL, RCOR1, and KAT6A), kinases (RPS6KA, MUSK, TRIM28, MPZL1, and MAP2K2), and phosphates (LPAR1, PICALM, RPS6KB1, DLG2, PPP6RB, TPTA, and PI4KA) were frequently present.
Viral integrants were detected into or close to various cellular genes that have been previously identified and novel ones including DLG2, FHIT, HMGA2, KLF5, KLF12, LRP1B, LEPREL1, MYC, and SEMA3D genes [53].
For instance, study identified novel association between certain genes with chronic diseases in Hispanic population, but in non-Hispanic the significance was rather limited, including the two novel loci (rs858249 and rs286499) in or near the genes KLHL7/NUPL2 and DLG2 [27].
However, most hits were found relevant and of particular note were Discs large homolog 2 (Dlg2), Myosin, light chain 4 (Myl4) and Fatty acid binding protein 3 (Fabp3).
For neuronal regeneration, 473 methylated genes were identified, like Bhlhb9, Cckar, Klhl1, Dlg2, and others.