We analyzed the characteristics of the gene partners (see details in Supplementary Table 1) to potentially define the molecular functions of the identified fusions, and we observed that chromatin modifiers (KMTA2-MLL, RCOR1, and KAT6A), kinases (RPS6KA, MUSK, TRIM28, MPZL1, and MAP2K2), and phosphates (LPAR1, PICALM, RPS6KB1, DLG2
, PPP6RB, TPTA, and PI4KA) were frequently present.
Viral integrants were detected into or close to various cellular genes that have been previously identified and novel ones including DLG2
, FHIT, HMGA2, KLF5, KLF12, LRP1B, LEPREL1, MYC, and SEMA3D genes .
For instance, study identified novel association between certain genes with chronic diseases in Hispanic population, but in non-Hispanic the significance was rather limited, including the two novel loci (rs858249 and rs286499) in or near the genes KLHL7/NUPL2 and DLG2
However, most hits were found relevant and of particular note were Discs large homolog 2 (Dlg2
), Myosin, light chain 4 (Myl4) and Fatty acid binding protein 3 (Fabp3).
For neuronal regeneration, 473 methylated genes were identified, like Bhlhb9, Cckar, Klhl1, Dlg2
, and others.