All of these proteins possess three independent PDZ (PSD-95, Dlg1
, and zonula occludens-1 proteins (zo-1)) domains through which they interact with glutamate receptors, cell adhesion molecules, and cytoskeletal elements.
Reduced cortical expression of a newly identified splicing variant of the DLG1
gene in patients with early-onset schizophrenia.
In TNBC, Akt3-MAGI3 fusions have been reported to upregulate the expression of AKT3, while removing the PDZ [PSD95 (postsynaptic density protein), Dlg1
(Drosophila disc large tumor suppressor), and zo-1 (zonula occludens-1 protein)] domain of MAGI3, required for PTEN binding.
MARCH2 down regulates TfR, B7.2, DLG1 and [[beta].sub.2]-adrenergic receptor ([[beta].sub.2]AR) [31, 63, 64].
DLG1, a modular scaffolding protein that plays an important role in controlling cell polarity , was identified as a target that binds to the PDZ domain of MARCH2.
Xavier, "DLG1 is an anchor for the E3 ligase MARCH2 at sites of cellcell contact," Cellular Signalling, vol.
MTMR2 dephosphorylates PI(3,5)P, which regulates membrane homeostasis and endosomal transport and has been described to interact with Disc large-1 (Dlg1), which is involved in polarised membrane trafficking .
Cuche et al., "Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse," The EMBO Journal, vol.
For lncRNA eHIT000015952, it was located on chromosome 3 and seven protein-coding genes (such as PAK2, MFI2, and DLG1
) were near its 300 kb area (data not shown).