DLEC1

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DLEC1

A gene on chromosome 3p21.3 that spans 59 kb, which may be deleted in certain malignancies and encode nonfunctional proteins. Aberrant DLEC1 transcription may be involved in carcinogenesis of the lung, oesophagus and kidney.
References in periodicals archive ?
When this happens DLC1 is no longer able to respond to biochemical signals telling a cell to die.
The scientists found that 54 out of 60 patients whose tumours were examined had elevated levels of DLC1.
A more detailed analysis revealed that five out of six samples had high levels of the modified form of DLC1.
In mice genetically engineered to over-produce DLC1, cells were found to move faster than normal, reproduce more quickly, and grow without normal cell-to-cell contacts.
The researchers traced the cancer-triggering modification to a tiny change in a chain of 19 amino acid protein building blocks in DLC1.
When his team engineered a form of DLC1 missing the modification-sensitive site, the protein no longer formed tumours.