DIO1

DIO1

A gene on chromosome 1p33-p32 that encodes a thiol-requiring propylthiouracil-sensitive oxidoreductase. DIO1 activates thyroid hormone by converting the prohormone thyroxine (T4) by outer-ring deiodination to bioactive 3,3’,5-triiodothyronine (T3). It also degrades T3 and T4 by inner-ring deiodination.
References in periodicals archive ?
3B); DIO1, deiodinase, iodothyronine, type I; VHL, von Hippel--Lindau tumor suppressor, E3 ubiquitin protein ligase; HIF1A, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); KLK10, kallikrein-related peptidase 10; KLK1, kallikrein 1; KLK15, kallikrein-related peptidase 15.