DIO1

DIO1

A gene on chromosome 1p33-p32 that encodes a thiol-requiring propylthiouracil-sensitive oxidoreductase. DIO1 activates thyroid hormone by converting the prohormone thyroxine (T4) by outer-ring deiodination to bioactive 3,3’,5-triiodothyronine (T3). It also degrades T3 and T4 by inner-ring deiodination.
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In normal nutritional conditions, the liver is the primary source of plasmatic T3, due to liver deiodination of T4 by Dio1 (which actually contributes to the release of T3 by the thyroid).
[4] Human genes: MIR, microRNA gene family; API5, apoptosis inhibitor 5; AP2M1, adaptor-related protein complex 2, mu 1 subunit; CDC42, cell division cycle 42 (GTP binding protein, 25 kDa); CXCR4, chemokine (C-X-C motif) receptor 4; SMAD4, SMAD family member 4; SMAD5, SMAD family member 5; SLMAP, sarcolemma-associated protein; H3.3B, H3 histone, family 3B (H3.3B); DIO1, deiodinase, iodothyronine, type I; VHL, von Hippel--Lindau tumor suppressor, E3 ubiquitin protein ligase; HIF1A, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); KLK10, kallikrein-related peptidase 10; KLK1, kallikrein 1; KLK15, kallikrein-related peptidase 15.
###Iodothyronine-deiodinase (DIO1)###Liver, kidneys, and thyroid'6
The DIO1 through DIO8 data lines carry data and command messages.
The PCR primers were as follows: for human GAPDH, forward 5'-TGATGACATCAA GAAGGTGGTGAAG-3' and reverse 5'-TCCTTGGAGGCC ATGTGGGCCAT-3'; for human DIO1, forward 5'-TTAG TTCCATAGCAGATTTTCTTGTCA-3' and reverse 5'-CT GATGTCCATGTTGTTCTTAAAAGC-3'; and for human DIO2, forward 5'-TCA-TTCTGCTCAAGCACGTG-3' and reverse 5'-ACCATTGCCACTGTTGTCAC-3'.
There are two types of deiodinases in thyroid, type 1 and type 2 (DIO1 and DIO2) [12, 13].