DHX15

DHX15

A gene on chromosome 4p15.3 that encodes a putative member of the Asp-Glu-Ala-His (DEAH)-motif-containing family of ATP-dependent RNA helicases, which is implicated in pre-mRNA splicing and involved in disassembly of spliceosomes after the release of mature mRNA.
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In addition, nanoceria treatment has been shown to induce glutathione oxidation, lipid peroxidation, and membrane damage in lung cancer cells and also suppress malignant activity of gastric cancer by increasing the expression of DHX15 [63,64].
New recurrent mutations were also identified, including alterations in DHX15, which has a role in modifying certain types of RNA.
The connectivity degree of certain genes exceeded 20, including DHX15, NDUFS3, PSMC6, UBE2C, EIF4G1, DHX9, PSMC3, and HNRNPA2B1 in the upregulated PPI network, and MAPK1, IL6, FN1, MAPK14, STAT3, and VWF in the downregulated PPI network (Table 1).