DHHC2 | definition of DHHC2 by Medical dictionary
ZDHHC2 (redirected from DHHC2)
ZDHHC2 A gene on chromosome 16q22.1 that encodes a DHHC-type zinc finger protein thought to be a palmitoyltransferase specific for GAP43 and DLG4/PSD95. It is highly expressed in foetal lung, kidney and heart.
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References in periodicals archive
For example, DHHC2 is expressed only in kidney and testis, whereas DHHC11 is expressed exclusively in testis .
More recent studies revealed that palmitoylation of GluA1 subunit requires its dynamic anterograde transport from the ER to the Golgi apparatus, while GluA2 subunits are palmitoylated by the ER-resided DHHC2 .
Primary results indicate that enzyme DHHC2
, DHHC3, DHHC8, and DHHC15 increases palmitoylation of DAT, while DHHC11 and DHHC7 have no effect when compared to control levels in LLCPK1 cells.