DHEA-S


Also found in: Acronyms.

DHEA-S

A steroid secreted by the cortex of the suprarenal gland and the testis; a precursor of testosterone. Limited studies suggest that DHEA reduces the percentage of body fat, perhaps by blocking the storage of energy as fat. Commercial formulations of DHEA are marketed as dietary supplements, although it is neither a nutrient nor a component of the human food chain. It has been promoted for the prevention of degenerative diseases including atherosclerosis, Alzheimer dementia, and parkinsonism and other effects of aging, but none of the alleged benefits has been confirmed in large, randomized clinical trials. Long-term administration to postmenopausal women has been associated with insulin resistance, hypertension, and reduction of low-density lipoprotein cholesterol.
References in periodicals archive ?
Lucky AW et al.23 in their study found that females with severe comedonal acne had significantly higher DHEA-S and testosterone levels.
Biochemical measurements were performed in a qualified laboratory using the DHEA-s, cortisol, and testosterone markers.
Total T, free T, androstenedione, DHEA-S, hCG, T4, FT4, and T3 were all found to decline significantly after 2 weeks of HM evacuation.
The concentrations of specific metabolites were significantly higher in IPD and T2DM patients, compared with the control group, including linoleic acid, oleic acid, docosanoic acid, cholesteryl-[beta]-D-glucoside, and 1,2-distearoyl phosphatidyl serine, whereas other metabolites, such as lysophosphatidylcholine (lysoPC), lysophosphatidyl ethanolamine (lysoPE), DHEA-S, and 5-hydroxykynurenine, were significantly lower in these groups.
Previous smaller studies had found an association between low DHEA-S levels and heart and blood-vessel, or cardiovascular, disease, although their results were inconclusive.
Aging is associated with a decrease in not only DHEA and DHEA-S but also in levels of follicle stimulating hormone (FSH), which stimulates the maturation of germ cells and regulates the development, growth, pubertal development and reproductive processes of the human body.
DHEA-S is a kind of steroid hormone which serves as an indicator of adrenal cancer and Cushing's syndrome, as well as metabolic diseases.
In women under age 45, there was a very strong independent association of low desire, arousal, and responsiveness with low DHEA-S levels, but no independent association with those sexual domains and testosterone levels.
At baseline, women with FSD had significantly decreased levels of testosterone and adrenal androgen precursors (dehydroepiandrosterone-sulfate or DHEA-S) but not ovarian androgen precursors (androstenedione), compared with women with normal sexual function.
MALES FEMALE (Luteal Phase) Hormone (LabCorp) Units Approximate Median Value DHEA-S pg/dL 347,400,000 271,600,000 Total Testosterone pg/dL 590,000 28,000 DHEA pg/dL 366,000 366,000 Pregnenolone pg/dL 100,000 100,000 Progesterone pg/dL 25,000 1,285,000 Total Estrogens pg/dL 7,750 25,300 Estrone (E1) pg/dL 4,200 8,200 Estradiol (E2) pg/dL 2,510 12,740 Free Testosterone pg/dL 1,790 210 As you can see, the level of DHEA-S (the form of DHEA tested in male and female panels) exceeds all the other steroid hormones combined!