NLRP1

(redirected from DEFCAP)

NLRP1

A gene located on chromosome 17p13.2 that encodes a member of the Ced-4 family of apoptosis proteins, which contain a caspase recruitment domain (CARD) and are key mediators of apoptosis. NLRP1 (formerly, NALP1) stimulates apoptosis by activating caspase-3.
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NLRP1 (also known as CARD7, NAC, DEFCAP, and NALP1) was the first identified NLR-family protein [5, 6] and differs from other NLR-family proteins in that its C-terminal region contains a nucleotide-binding domain (NBD).