Ly75

(redirected from DEC-205)

Ly75

A gene on chromosome 2q24 that encodes a C-type lectin-domain protein which acts as an endocytic receptor, directing captured antigens from the extracellular space to a specialised antigen-processing compartment. Ly75 also downregulates B-cell proliferation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Numerous receptors have been identified to be expressed on DCs, including mannose receptor (MR), DC-SIGN, scavenger receptor (SR), DEC-205, and toll-like receptors.
Interestingly, anti-DEC-205 monoclonal antibody was recently shown to be taken up by Langerin-positive DCs [124], suggesting there is cross-talk between DEC-205 and Langerin receptors.
DEC-205 (CD205 or lymphocyte antigen Ly 75) is a type-I integral membrane protein homologous to the macrophage MR family of C-type lectins, which binds carbohydrates and mediates endocytosis (Figure 1) [173].
In an attempt to design vaccines that target DEC205, the cytosolic tail of DEC-205 was fused to the external domain of the CD16 Fc gamma receptor and was studied in stable L cell transfectants [175].
Further, HIV p24 gag protein conjugated to anti-DEC205 monoclonal antibody, or HIV gag p24-single chain DEC-205 Fv DNA vaccines, was taken up by DCs and stimulated proliferation and IFN-gamma secretion by CD8+ T cells that had been isolated from HIV-infected donors [180,181].
Kelly et al., "Antibody-targeted NYE-SO-1 to mannose receptor or DEC-205 in vitro elicits dual human CD8+ and CD4+ T cell responses with broad antigen specificity," Journal of Immunology, vol.
Heufler et al., "The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing," Nature, vol.
Lee et al., "The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments," Journal of Cell Biology, vol.
Steinman, "Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance," Journal of Experimental Medicine, vol.