Genome-wide association studies have identified several genetic loci associated with increased risk of glioma, including TERT, CDKN2A/2B, RTEL1, PHLDB1, EGFR, TP53, TERC, DDX6, and PIWI-interacting RNAs.
Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility.
interaction with a P-body protein, Ddx6. Our research goal is the
identification of the binding site of Ddx6 on the E4 11k protein.
acids, we aim to ascertain if the binding of E4 11k with Ddx6 and
BINDING OF ADENOVIRUS EARLY PROTEIN E411K TO RNA HELICASE DDX6
research has indicated that the interaction between DDX6 and the 11-kDa
Manjunath, "P-body components LSM1, GW182, DDX3, DDX6
and XRN1 are recruited to WNV replication sites and positively regulate viral replication," Virology, vol.
DDX6 encodes a member of the DEAD box protein family, which has multiple functions including translation suppression and mRNA degradation (Weston and Sommerville, 2006).
Xp54 and related (DDX6 like) RNA helicases: roles in messenger RNP assembly, translation regulation and RNA degradation.
Interestingly, in the six clusters, we also observed that various genes involved in angiogenesis and/or in vascular damage were targeted by selected miRNAs including THBS1, MMP8, VEGFA (CL1), FOSL2, THBD (CL2), HIPK1 and DDX6
(CL3), PGK1 (CL4), and ACTR2 (CL6).
DETERMINATION OF THE BINDING SITE OF ADENOVIRUS E4 ORF3 AND DDX6
**, Julia A.