DDX5

DDX5

A gene on chromosome 17q21 that encodes a putatitive RNA helicase with a conserved Asp-Glu-Ala-Asp (DEAD) motif. DEAD box proteins are RNA-dependent ATPases thought to play a role in altering RNA secondary structure by translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
References in periodicals archive ?
Therefore present project was designed to isolate and clone DDX5 gene from human and to study its phylogenetic relation with different organisms.
The sequence alignment between clone and known DDX5 sequence was performed by using CLUSTAL W software.
BLAST (Basic Local Alignment Search Tool) has shown that this partial p68 gene sequence is 99% similar with Pan troglodytes DDX5 mRNA (AK306198.
To study the genetic evolution of the human DDX5 a phylogenetic tree (Fig.
It is suggested that DDX5 of Human sapiens and of Sus scrofa and Pan troglodytes have originated from same ancestors.
2011) identified DDX5 homolog (Cq-DDX5) in Cherax quadricarinatus (fresh water crayfish) where this homolog was found to play an important role in early ontogenesis and spermatogenesis.
These methods (23,45) have provided evidence that EGCG binds to several intracellular proteins such as vimentin and the ATP-dependent RNA helicase DDX5, indicating that EGCG can enter into the cell.
Human tumor cells (at left, each line represents one cell) that withstood a dose of the anticancer drug cam ptothecin made more of the DDX5 enzyme (as measured by fluorescence level), while enzyme levels dropped in the cells eventually killed by the treatment.