DDX46

DDX46

A gene on chromosome 5q31.1 that encodes a protein with a conserved Asp-Glu-Ala-Asp (DEAD) motif. DDX46 is a putative ATP-dependent RNA helicase that plays an essential role in splicing—either before or during—A complex formation.
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We then performed quantitative RT-PCR (Q-RT-PCR) on the same samples to analyze expression for a subset of 4 randomly selected genes, KIAA0101, UBE2D3, EPAS1, and DDX46, from the list of 40 differentially upregulated genes.
Finally, DDX46 encodes a member of the DEAD box protein family that has putative helicase activity and is involved in pre-mRNA splicing as part of the 17S U2 small nuclear ribonucleoprotein complex.
Gene symbol KIAA0101 EPAS1 UBE2D3 DDX46 Fold change microarray 4.5 5.5 4.1 4.1 Internal Fold change Q-PCR 6.6 6.4 5.1 1.3 Normal (n) CRC (n) (8) (11) (8) (11) (8) (11) (8) (11) KW P-value 0.01 0.09 0.001 0.96 External Fold change Q-PCR 1.5 2.8 1.6 1.1 Normal (n) CRC (n) (35) (28) (35) (28) (36) (29) (34) (27) KW P-value 0.14 0.0002 0.09 0.94 Pre/Post Fold change Q-PCR 0.5 0.1 0.6 1.2 Presurgery (n) (11) (11) (11) (11) (11) (11) (11) (11) postsurgery (n) KW P-value 0.72 0.0002 0.007 0.39