DDX42

DDX42

A gene on chromosome 17q23.3 that encodes a protein which has a conserved Asp-Glu-Ala-Asp (DEAD) motif and is a probable ATP-dependent RNA helicase. It binds to partially double-stranded RNAs to unwind RNA secondary structures, which is promoted in the presence of single-strand binding proteins. ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands.
References in periodicals archive ?
This duplex is then loaded into the miRISC, which includes an AGO2 protein, GW182/TNRC6 proteins, Gemin 3/4 (Deadbox helicases DDX20 and DDX42), among other potential proteins, and the mature functional guide single-stranded miRNA yielding a functional miRISC.
Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42. Virus research.