DDX3X | definition of DDX3X by Medical dictionary
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DDX3X A gene on chromosome Xp11.3-p11.23 that encodes a protein which contains a conserved Asp-Glu-Ala-Asp (DEAD) motif and acts as an ATP-dependent RNA helicase. It interacts with hepatitis C virus core protein, changing its intracellular location, and is a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs; it is also involved in HIV-1 replication.
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References in periodicals archive
van den Berg et al., "Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X
in complex with the mononucleotide AMP," Journal of Molecular Biology, vol.
biomarker correlates with poor survival in human gliomas.
Among the newly identified mutations was one in an RNA helicase gene, DDX3X
, which Cho said is the second-most common mutation in medulloblastoma tumors.