RNA helicase DDX3
is a regulatory subunit of casein kinase 1 in Wnt-[sz]-catenin signaling.
More recently, DDX3, a member of DEAD box RNA helicases, was found to interact with ALKBH5 through its ATP domain and DSBH domain of ALKBH5 to modulate mRNA demethylation activity.
Awan et al., "The DEAD-box RNA helicase DDX3 interacts with m6A RNA demethylase ALKBH5," Stem Cells International, vol.
P53 inactivation can lead to DDX3 loss, which subsequently results in Slug-suppressed E-cadherin expression via decreased MDM2-mediated Slug degradation .
Lee, "DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer," Oncogene, vol.
Interestingly, LGP2 sentinel function seems to be shared by many other DExD/H box RNA helicases such as DDX3
, DHX9, DHX29, and DDX41, which bind directly to nucleic acids and interact with either RIG-I or MAVS to activate the pathway (see [60, 61]).
Reed, "Human DDX3
functions in translation and interacts with the translation initiation factor eIF3," Nucleic Acids Research, vol.
DEAD-box RNA helicases include yeast Dhh1 and Ded1, human Rck and DDX3, Drosophila Me31B, Plasmodium DOZI, Toxoplasma TgHoDI and TgeIF4a, and Caenorhabditis CGH-1, all of which are found in both SGs and PBs .
Wu Lee, "Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response," Biochemical Journal, vol.
The RNA helicase DDX3
is a component of P bodies and is required for HCV RNA replication (154).
reported that DDX3
, a member of the family of DEAD box RNA helicases, functions as a regulator for ALKBH5 which can catalyze demethylation of the m6A in mRNAs.
is multifunctional and is ubiquitously expressed in a wide range of tissues [7, 8].