DDX21

DDX21

A gene on chromosome 10q21 that encodes a protein which has a conserved Asp-Glu-Ala-Asp (DEAD) motif and, as an ATP-dependent RNA helicase, unwinds double-stranded RNA but can also introduce a secondary structure to a single-stranded RNA, acting as a foldase. It acts as a cofactor for JUN-activated transcription. DDX21 is also a less preferred gene symbol for what is now designated as DDX56, see there.
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Many of the currently known G4-binding proteins have RGG/RG motifs [29, 39], some of which have been shown to be critical to G4 binding and recognition, including the translated in sarcoma/fused in sarcoma (TLS/FUS) [40], nucleolin (NCL) [41], Ewing's sarcoma protein (EWS) [42], Epstein Barr virus nuclear antigen 1EBNA1 [43], DDX21 [44], and fragile X mental retardation protein (FMRP) [45].
McKenna, "Human DDX21 binds and unwinds RNA guanine quadruplexes," Nucleic Acids Research, vol.