DDX10 | definition of DDX10 by Medical dictionary
DDX10 A gene on chromosome 11q22-23 that encodes a putative ATP-dependent RNA helicase which contains a conserved Asp-Glu-Ala-Asp (DEAD) motif. RNA helicases are implicated in various processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
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References in periodicals archive
The SNP on Chr15 were located in an intron of DEAD box polypeptide 10 (DDX10
), which is associated with leukemia (Nishiyama et al., 1999; Nakao et al., 2000; Morerio et al., 2006).
The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10
. Blood 1997; 89: 3936-44.