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DDR2A gene on chromosome 1q23.3 that encodes a receptor tyrosine kinase belonging to the subfamily homologous to Dictyostelium discoideum protein discoidin (Discoidin Domain-containing Receptor); it is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a MAP kinase-signalling pathway, activating the transcription factor RUNX2; it regulates remodelling of the extracellular matrix by upregulating collagenases MMP1, MMP2 and MMP13, facilitating cell migration and tumour cell invasion. DDR2 promotes fibroblast migration and proliferation, contributing to wound healing.
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