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Danon's disease



A rare X-linked lysosomal storage disease whose clinical features often include cardiomyopathy, skeletal myopathy, and mental retardation.
Synonym: X-linked vacuolar cardiomyopathy and myopathy

Degos disease



A rare form of vasculitis that damages small blood vessels. The disease initially results in tissue infarction within the skin, but in some instances causes widespread and occasionally fatal tissue infarction in the gastrointestinal tract and other organs.
Synonym: malignant atrophic papulosis

differential display



A gene-screening technique used to analyze the ways in which different types of messenger RNA are expressed in organisms.


(dis'tro-fe) [ dys- + -trophy]
A disorder caused by defective nutrition or metabolism. dystrophic (dis-tro'fiik), adjective

adiposogenital dystrophy

Fröhlich syndrome.

asphyxiating thoracic dystrophy

Jeune syndrome.

Becker muscular dystrophy

See: Becker muscular dystrophy

Bietti crystalline dystrophy

See: Bietti crystalline dystrophy

cone-rod dystrophy

A form of retinitis pigmentosa in which central visual loss occurs first. Common symptoms include progressive visual loss followed by the loss of color perception, and eventually peripheral visual loss and night blindness. The visual loss is not correctable with standard lenses. See: retinitis pigmentosa

congenital hereditary endothelial dystrophy

Abbreviation: CHED
An eye disorder in which the corneal endothelium becomes cloudy, resulting in myopia.

corneal dystrophiy

Any of several inherited disorders in which the cornea becomes cloudy, hazy, or speckled, resulting in variable degrees of visual loss.

corneoretinal dystrophy

Bietti crystalline dystrophy.

distal muscular dystrophy

Abbreviation: DD
One of several rare forms of muscular dystrophy in which the forearm, hand, calf, and foot muscles are primarily affected as opposed to the muscles of the shoulders or pelvic girdle. Its onset is usually in adults between the ages of 40 and 60. Synonym: distal myopathy

Duchenne muscular dystrophy

See: Duchenne, Guillaume B. A.

Emery-Dreifuss muscular dystrophy

See: Emery-Dreifuss muscular dystrophy

facioscapulohumeral muscular dystrophy

A hereditary, progressive muscular dystrophy with onset in childhood or adolescence. It is marked by atrophic changes in the muscles of the shoulder girdle and face, inability to raise the arms above the head, myopathic facies, eyelids that remain partly open in sleep, and inability to whistle or purse the lips.


Therapy is supportive; e.g., orthopedic devices can be used to prevent functional losses at the shoulder girdle. The patient should be encouraged to maintain as full and normal a life as possible and to avoid prolonged bed rest.

macular dystrophy

Any inherited, progressive degeneration of the macula lutea retinae marked by progressive central visual loss beginning in childhood or adolescence. Representative forms of macular dystrophy include Best disease and Stargardt disease. See: macula lutea retinae

muscular dystrophy

Any of nine distinct genetic syndromes that affect muscular strength and action, some of which first become obvious in infancy, whereas others manifest in adolescence or young adulthood. The syndromes are marked by either generalized or localized muscle weakness, difficulties with walking or maintaining posture, muscle spasms, and sometimes neurological, behavioral, cardiac, or other functional limitations. Detailed information about the disease can be obtained from the Muscular Dystrophy Association website at www.mdausa.org.

myotonic dystrophy

Abbreviation: DM
An autosomal dominant disorder caused by the repeated expansion of the trinucleotide sequence cytosine-thymidine-guanine (CTG)) in the DNA of chromosome 19. It is the most commonly inherited of the muscular dystrophies.

oculopharyngeal muscular dystrophy

Abbreviation: OPMD
A rare form of muscular dystrophy in which muscles that control the eyelids and swallowing are primarily affected. Ptosis and dysphagia beginning in the patient's late 40s or early 50s are characteristic symptoms. Weakness in the limbs often follows. The disease occurs most often in French-Canadian or Hispanic kindreds.

progressive muscular dystrophy

Spinal muscular atrophy.

pseudohypertrophic muscular dystrophy

Duchenne muscular dystrophy.

reflex sympathetic dystrophy

An abnormal response of the nerves of the face or of an extremity, marked by pain, autonomic dysfunction, vasomotor instability, and tissue swelling. Although the precise cause of the syndrome is unknown, it often follows trauma, stroke, neuropathy, or radiculopathy. In about one third of all patients, the onset is insidious. Affected patients often complain of burning pain with any movement of an affected body part, excessive sensitivity to light touch or minor stimulation, temperature changes (heat or cold) in the affected limb, localized sweating, localized changes of skin color, or atrophic changes in the skin, nails, or musculature. Synonym: algodystrophy; complex regional pain syndrome, type 1; shoulder-hand syndrome; Sudeck disease


Early mobilization of the body part with multimodality therapy may improve the symptoms of reflex sympathetic dystrophy. Drug therapies often include prednisone or other corticosteroids and narcotic analgesics; trancutaneous electrical stimulation, physical therapy, or nerve blocks may also prove helpful.

rod-cone dystrophy

A form of retinitis pigmentosa in which rod degeneration precedes cone degeneration. Night blindness is usually the first symptom, followed by peripheral visual loss.

Schnyder crystalline dystrophy

See: Schnyder crystalline dystrophy

twenty-nail dystrophy

Longitudinal ridging and fragmentation of all the fingernails and toenails. It is a characteristic finding in lichen planus.

vitelliform dystrophy

Vitelliform macular dystrophy.

vitelliform macular dystrophy

An autosomal dominant retinal disease in which central visual acuity is diminished when lipofuscin accumulates under the macula. When the disease occurs in childhood, it is called Best disease.

vulvar dystrophy

Lichen sclerosus et atrophicus.

distal muscular dystrophy

Abbreviation: DD
One of several rare forms of muscular dystrophy in which the forearm, hand, calf, and foot muscles are primarily affected as opposed to the muscles of the shoulders or pelvic girdle. Its onset is usually in adults between the ages of 40 and 60. Synonym: distal myopathy
See also: dystrophy
Medical Dictionary, © 2009 Farlex and Partners

Distal muscular dystrophy (DD)

A form of muscular dystrophy that usually begins in middle age or later, causing weakness in the muscles of the feet and hands.
Mentioned in: Muscular Dystrophy
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
DDEs with strong social orientation have a sense of responsibility for the life quality of their local employees.
During the integration of DDEs, the delay time may even lie in the previous step, current step, or in the next step.
A prospective study of 802 infants found that although higher transplacental exposure to PCBs was associated with lower Bayley psychomotor scores at 6 and 12 months of age, such an association was not present in children exposed to PCBs or dichloroethane (DDE) via breast milk (Gladen et al., 1988).
The DDEs were upgraded in the early 1960s to accommodate the newly acquired (now much maligned) CH-124 Sea King anti-submarine helicopters.
FAMILY SERVS., DDES INFO MEMO 2004-03 (June 22, 2004), available at
The research interview captured participants' social resources with the 11-item Duke Social Support Index (DSSI) (Koenig et al., 1993), number of life events with the Duke Life Event Scale (Blazer, Hughes, & George, 1987; Hughes, Blazer, & George, 1988), and perceived stress during the past six months with the DDES (Krishnan et al., 1995).
Army, Air Force, NASA, and the DOD Explosives Safety Board (DDES B).
Treatment of the Ishikawa(AP-1)+ cells revealed that the DDTs, DDDs, and DDEs could all significantly stimulate AP-1 activity, with the DDTs and DDDs having the greatest activity on average.
They were designated DDEs because they were anti-submarine destroyers.
A new teaching software from DDES Corporation is designed for K-12 schools, colleges, training institutions and corporate training environments.