p21 cooperates with DDB2
protein in suppression of ultraviolet ray-induced skin malignancies.
The polymorphisms of multiple genes involved in NER pathways are associated with different prognostics of gastric cancer; for example, excision repair cross-complementing group 2 (ERCC2) and excision repair cross-complementing group 6 (ERCC6) are associated with poor prognostic, while ERCC1, ERCC5, and DDB2
predict longer overall survival (13).
Other mechanisms by which PEITC induces apoptosis (at 50 /M) include the increase of DDB2
(damaged DNA-binding protein 2) expression, as observed in colon cancer cells (HCT 116) in vitro and in vivo , as well as the activation of the extrinsic apoptotic pathway (death receptor-mediated apoptosis), as observed in oral and cervical cancer cells .
BRCA1, BRCA2, DDB2
, MGMT, MLH1, POLB UNG, XPA genes might be possible clue for developing breast cancer.
Genes Tested AtP ALK APC ATM BAP1 BRCA2 BRIP1 BUB1B CDC73 CDH1 CEP57 CHEK2 CYLD DDB2
DICER1 ERCC3 ERCC4 ERCC5 EXT1 EXT2 FANCD2 FANCE FANCF FANCG FANCI GATA2 GPC3 HNF1A HOXB13 HRAS MLH1 MHS2 MSH6 MUTYH NBN PHOX2B PMS1 PMS2 PPM1D PRF1 RAD51D RBI RECQL4 RET RHBDF2 SDHC SDHD SLX4 SMAD4 SMARCA4 TP53 TSC1 TSC2 VHL WT1 BARD1 BLM BMPR1A BRCA1 CDK4 CDKN1C CDKN2A CEBPA DI53L2 EGFR EPCAM ERCC2 EZH2 FANCA FANCB FANCC FANCL FANCM FH FLCN KIT MAX MEN1 MET NF1 NF2 NSD1 PALB2 PRKAR1A PTCH1 PTEN RAD51C RUN XI SBDS SDHAF2 SDHB SMARCB1 STK11 5UFU TMEM127 WRN XPA XPC This chart shows all 98 cancer susceptible genes included in this new test.
Among these genes, 9 [aprataxin (APTX), aprataxin and PNKP like factor (APLF), X-ray repair cross complementing 4 (XRCC4), BRCA1 interacting protein C-terminal helicase 1 (BRIP1), Fanconi anemia complementation group B (FANCB), Fanconi anemia complementation group M (FANCM), damage specific DNA binding protein 2 (DDB2
), XPC complex subunit, DNA damage recognition and repair factor (XPC), and mutL homolog 3 (MLH3)] were over-expressed in CTC-MCC-41 cells and only 4 [DNA polymerase mu (POLM), RAD51 recombinase (RAD51), ERCC excision repair 1 (ERCC1), and tumor protein p53 binding protein 1 (TP53BP1)] in HT-29 cells.
A commercial Xeroderma Pigmentosum Next Generation Sequencing panel including the genes DDB2
, ERCC2, ERCC3, ERCC4, ERCC5, POLH, XP-A, and XPC revealed a homozygous germline sequence variant designated c.547A>T in the XPC gene, which was confirmed by Sanger sequencing.
In order to obtain a thorough understanding on DNA repair mechanism on cell-TNA interaction, important genes, namely, RAD50, DDB2
, XRCC5, XRCC6, ATM, THP0, ANGPTL6, and MRE11A, were further profiled at mRNA expression level on epithelial HT29 cells compared to control surfaces, namely, plastic, glass, and TiP (Figure 4(b)).
Several genes found to be consistently affected by radiation are part of the transformation related protein 53 [p53 (Trp53)] DNA damage response: cyclin-dependent kinase inhibitor lA (Cdkn 1a), growth arrest and DNA-damage-inducible 45 alpha (Gadd45a), transformed mouse 3T3 cell double minute 2 (Mdm2), ataxia telangiectasia mutated homolog (human) (Atm), and damage specific DNA binding protein 2 (Ddb2
) (Gruel et al.
Otro de los problemas cruciales sobre los que no se pudo profundizar, fue sobre el impacto que tiene el ejercicio fisico en los marcadores tumorales asociados al cancer de mama [ErbB-2, P53 FOSFOPROTEINA, proliferacion celular (Ki67), BRCA1, PCNA, receptores hormonales ER/PR, Bcl-2, DDB2
proteina, P27 PROTEINA, SKP2, IGF1, IGF2, IGFBP1-3, Estradiol] y de esta forma plantear las posibles vias y mecanismos biologicos de accion.
is the employee's deemed death benefit at the end of the policy year; DDB1 is the employee's deemed death benefit at the end of the preceding policy year; and X is the premium for one dollar of paid-up whole life insurance at the employee's attained age at the beginning of the policy year.