On chromosome 6 there are several protein coding sequences in near vicinity of the locus rs109210955, including leucine aminopeptidase (LAP3), mediator of RNA polymerase II transcription subunit 28 (MED28), family with sequence similarity 184 member B (FAM184B), DDB1
and CUL4 associated factor 16 (DCAF16), non-SMC condensin I complex subunit G (NCAPG), ligand-dependent nuclear receptor corepressor-like protein (LCORL).
For some types of DNA lesions, including CPDs and 6-4 PPs, damage recognition is supported by proteins DDB1 and 2 (DNA damage-binding proteins 1 and 2).
Additionally, a negative regulation of the genes encoding the proteins involved in the NER pathway in SLE patients, specifically DDB1, ERCC2, XPA, and XPC, has been found [71, 86].
HBx protein also interacts with cell cycle and DNA repair regulator known as UV-damaged DNA binding protein 1 (DDB1
Patients whose tumors had gains containing the BIRC5 gene and the DNA damage-binding protein (DDB1
) gene (11q12.2) had inferior survival, but the study was limited to small numbers of patients.
DDB2 is the employee's deemed death benefit at the end of the policy year; DDB1
is the employee's deemed death benefit at the end of the preceding policy year; and X is the premium for one dollar of paid-up whole life insurance at the employee's attained age at the beginning of the policy year.
CRBN interacts with the DNA damage-binding protein-1 (DDB1
), Cullin 4 (Cul4A or Cul4B), and regulator of Cullins 1 (RoC1) to form the functional E3 ubiquitin ligase complex.
The formula for determining the annual cost of the permanent benefit is: X(DDB2 - DDB1