DST

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DST

A gene on chromosome 6p12.1 that encodes dystonin, a cytoskeletal linker protein which integrates intermediate filaments, actin and the microtubule cytoskeleton network, and is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional reticulum.

DST isoform 3 plays a structural role in assembling hemidesmosomes of epithelial cells; it anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes and is required for regulating keratinocyte polarity and motility; it mediates integrin ITGB4 regulation of RAC1 activity. DST isoform 6 is required for bundling actin filaments around the nucleus. DST isoform 7 regulates the organisation and stability of the microtubule network of sensory neurons to allow axonal transport.

Molecular pathology
Defects of DST cause hereditary sensory and autonomic neuropathy type 6.
References in periodicals archive ?
Method Formulae DD1 (Tm-Tb)+(TM-Tm)/2 DD2 [summation](T-Tb)/24 DD3 {[([T.sub.i]-Tb)+([T.sub.i+1]-Tb)]/2} ([t.sub.i+1]-[t.sub.i]) Method Constraints DD1 If Tm<Tb: DD1 = [(TM-Tb).sup.2]/[2.(TM-Tm)] If T<Tb [right arrow] T=Tb DD2 If To<T[less than or equal to]Tc: (T-Tb) [??] [(To-Tb).(Tc-T)]/(Tc-To) DD3 If T<Tb or T>Tc [right arrow] zero DD1 = Method using median daily temperatures; DD2 = Method using daily mean temperatures; DD3 = Method using trapezoid area.
Let us start with the test local cis-area and local trans-area in rectangular region of [-19.2[degrees] < DD1 < -59.2[degrees], 30.9[degrees] < DD2 < 70.9[degrees]] and [-180.0[degrees] < DD1 < -144.3[degrees], 16.7[degrees] < DD2 < 56.7[degrees]], respectively, for both initial and final conditions of trajectories.
What are the most effective DD1 & DD2 professional development components as measured by changes in teacher perceptions and practices?
Because DD2 is the nation's top game I've decided to have a lucky dip.
Inquiry regarding the extent to which DD1 and DD2 has impacted teaching and learning across the United States is based upon the following five questions:
It was bitter disappointment for Luke Varley who never put a foot wrong all week in the DD2 class, winning two of his Heats and finishing second in the Pre-final.
understanding and initial skill acquisition; DD2 provides more in-depth training during a second year after educators have had an opportunity to implement basic program strategies for a full academic school year.
Muscat: Oman's DD2 champions Abdullah Al Rawahi along with his teammates on a strong UAE and Oman contingent has reached the Mediterranean City of Naples, Southern Italy, to take part in the 2016 Rotax Max Challenge Grand Finals.
Tony Hogg was the top DD2 Masters driver from Team UAE with the 56th best time, followed by Hussein Umid Ali 67th and Jonathan Mowatt was 71st.
He managed to claim his own two victories in the BRMMC's DD2 division.
Tay Valley Gundog Association's Limited Show in Carnoustie, secretary Mrs E Farningham, 142 Liff Road, Dundee DD2 2TS.
Varley, the 2009 MAX Champion, used all of his experience to secure second place on the DD2 grid which includes ex-Formula 1 driver and grand prix winner Rubens Barrichello from Brazil among the 72 DD2 champions from around the world.