NRAMP

(redirected from DCT1)
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NRAMP

A protein of the solute carrier family 11, encoded by SLC11A1 on chromosome 2q35, which transports iron and other divalent metals (e.g., manganese, cobalt, zinc, cadmium and lead) across the apical membrane of enterocytes in the brush border of the GI mucosa and into cells by a proton-coupled process.
 
Abnormal in
Mutations of SLC11A1 have been associated with increased susceptibility to infections (e.g., tuberculosis and leprosy), and inflammatory diseases (e.g., rheumatoid arthritis and Crohn’s disease).
References in periodicals archive ?
Divalent metals Fe, Cu, Ag, and zinc (DMT1, DCT1, and Nramp2) transports, ferroprotein, Divalent metals Fe3+ and cobalt Divalent metal transporter (Co2+), Ca++, Fe++, 1, divalent cation Mn++, Cd++, Cu++, transporter 1 (DCT1) Ni++, Pb++, Zn ++ Trivalent metals Al and Mn Diferric transferrin Methyl mercury Transport by the L-cysteine system Element Functions References Molybdenum Cofactor or activator of certain enzymes (e.g., nitrogen fixation, nucleic acid metabolism, and aldehyde oxidation) Cobalt Constituent of vitamins [B.sub.12] Copper Constituent of plastocyanin and [28-32] cofactor of respiratory enzymes.
DMT-1 Also known as DCT1, Nramp2, BMP identified as homologue of Nramp1, a protein that confers resistance to intracellular pathogens.
[5] Human genes: HFE, hemochromatosis; HJV (alias, HFE2), hemochromatosis type 2 (juvenile); HAMP, hepcidin antimicrobial peptide (alias, LEAP-1); SMAD4, mothers against DPP homolog 4 (Drosophila); TfR2, transferrin receptor 2 (alias, HFE3); SLC40AI, solute carrier family 40 (iron-regulated transporter), member 1 (aliases, IREG1, FPN1, HFE4); FTL, L-ferritin; and SLCIIA2, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (aliases, DMT1, DCT1, and NRAMP2).