SAMHD1

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SAMHD1

A gene on chromosome 20pter-q12 that encodes a putative nuclease involved in the innate immune response, which acts by downregulating cell-intrinsic antiviral response. It may play a role in mediating pro-inflammatory responses to TNF-alpha signalling. It is expressed in the heart, skeletal muscle, spleen, liver and elsewhere, but not in the brain or thymus.

Molecular pathology
Defects in SAMHD1 cause Aicardi-Goutieres syndrome type 5 and chilblain lupus type 2.
References in periodicals archive ?
Moments later, around six soldiers physically assaulted and dragged him to a nearby settlement before calling an ambulance, Hatem told DCIP.
The DCIP will help us reliably protect and control risks in trade finance transactions, which in turn will help us better support the trading needs of Arab energy companies and enhance our trade-finance business growth.
Apicorp CEO and general manager Ahmad Bin Hamad Al-Nuaimi said: "We are extremely happy to advance our co-operation with the ICIEC by signing the DCIP.
Taha added: "This signed DCIP between ICIEC and APIRCORP is the first signed between ICIEC and a joint Arab Financial Institution and represents a beneficial alliance between two sister multilateral institutions.
DCIP deletes itemsets lower than the minimum support in order to reduce the data size to be scanned.
Like every new adventure, the DCIP has its strengths and challenges.
developed a comprehensive management plan to implement DCIP and (2)
DOD's DCIP guidance requires the combatant commands and the military services to conduct annual DCIP exercises, either separately or in conjunction with existing exercises.
As a result of those efforts, in early 2006, the Assistant Secretary of Defense for Homeland Defense and America's Security Affairs (ASD (HD&ASA)) issued a comprehensive set of DCIP benchmarks and standards for use with existing IVA protocols.
The standard screening blood tests OF and DCIP involved sending the samples to a central location, which was costly.
The criterion variable is the generated factor score on the latent variable DCIP, and the predictor variables are the selected variables related to qualifications.