In our study, we found that the over expression of DKK4 might promote the proliferation of tumor cells with unclear mechanism and that there is over expression in genes related to cell adhesion, such as FAT3 , PCDH family (including PCDHAI , PCDHB16 , and PCDH14 ), CDH11 , and
DCHS1 , and they participate in the adhesion, migration, differentiation, and signal transmission of cells by adjusting the intercellular interaction and interaction between cell and extracellular matrix; they might also be relevant to the progression of GST.
All CDH genes (n = 27) screened in this study include CDH1 (E-cadherin), CDH2 (N-cadherin), CDH3 (P-cadherin), CDH4 (R-cadherin), CDH5 (VE-cadherin), CDH6 (K-cadherin), CDH7 (cadherin 7), CDH8 (cadherin 8), CDH9 (T1-cadherin), CDH10 (T2-cadherin), CDH11 (OB-cadherin), CDH12 (N-cadherin 2), CDH13 (H-cadherin), CDH15 (M-cadherin), CDH16 (KSP-cadherin), CDH17 (LI-cadherin), CDH18 (cadherin 18), CDH20 (cadherin 20), PCDHGA12 (CDH21), CDH22 CDH23 CDH24
DCHS1 (CDH19, or CDH25), CDH26 DCHS2 (CDH27), CDHR3 (CDH28), and CDHR4 (CDH29).