DCAF11A gene on chromosome 14q11.2 that encodes a WD-repeat-containing protein that interacts with the COP9 signalosome. COP9 is a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolysing cullin-Nedd8 conjugates. DCAF11 may act as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
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