CD209

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CD209

A gene on chromosome 19p13 that encodes a pathogen-recognition receptor expressed on the surface of immature dendritic cells which is involved in initiating a primary immune response. These receptors are thought to recognise high mannose N-linked oligosaccharides present on the surface of pathogens (such as HIV-1, HIV-2 and SIV gp120, amongst others) in a calcium-dependent fashion. Once bound, the receptor mediates endocytosis of the pathogens, which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface, while the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
References in periodicals archive ?
The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells," The Journal of Immunology, vol.
DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells.
Two micrometre sections were cut onto poly-L-lysine coated slides and stained with DC-SIGN (purified mouse antihuman CD209 antibody, dilution 1:40, BD Biosciences, US) and DC-SIGNRs (monoclonal antihuman CD209L antibody, dilution 1:40, R&D systems, US) using the Envision kit.
While it has been known for some time that dengue used DC-SIGN to attach to cells, Liu and her colleagues used high-resolution microscopy to study exactly how the viruses used the protein to gain entry into cells.
Genotyping of CCR2, MCP-1, SDF-la and DC-SIGN exon4 repeat polymorphisms: Genomic DNA was isolated from peripheral blood mononuclear cells and granulocytes obtained from the blood of patients and healthy controls using salting out procedure (18).
Ademas, las DCM tambien expresan receptores tipo lectina, como DC-SIGN (CD209), DEC205 (CD205), los receptores de manosa (CD206) y la langerina (CD207), moleculas implicadas en la union e internalizacion del VIH-1 hacia compartimentos endosomales (11).
Figdor, and AIDS researchers at New York University now report in the March 3 CELL that HIV uses its gp120 to bind to a dendritic cell's DC-SIGN.
In this work, we found that the mRNA expressions of DC-SIGN enhanced by the supernatants of both T1a and T [sub]XHB , but the time and extent of enhancement were different.
The team found that DC-SIGN binds to major allergen from house dust mite (Der p 1) and dogs (Can f 1) and seems to play a regulatory role in the allergic response to house dust mite allergens.
pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN.
3] investigate the potential role of DC-SIGN and related molecules in the vertical transmission of HIV.