PKN1

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PKN1

A gene on chromosome 19p13.12 that encodes a PKC-related serine/threonine-protein kinase involved in various cellular processes, including regulation of intermediate filaments of the actin cytoskeleton, cell migration, tumour cell invasion and transcription regulation. PKN1 regulates the cytoskeletal network by phosphorylating VIM and neurofilament proteins (e.g., NEFH, NEFL and NEFM), inhibiting their polymerisation; it is a coactivator of androgen receptor.
References in periodicals archive ?
DBK is moving to a new loft-style office overlooking the Rotunda in Bradford Street after 20 years in the Jewellery Quarter.
As well as marketing the new service to insolvency practitioners and funders, DBK is also offering 'health checks' and contract reviews to developers and contractors.
The listing committee at the Egyptian Stock Exchange (EGX) approved in April 2015 to list the shares of DBK Pharma Co with capital of EGP 149.2m.
RPS said: "DBK has enjoyed an incredible decade of growth and employs an extremely talented and enthusiastic workforce.
In the year to 31 December 2015, DBK had revenues of GBP 12.1m and profit before tax of GBP 2m, after adjustment for non-recurring items.
To match the long maturities of its loans, DBK relies heavily on long-term wholesale borrowings.
The daily has learned that PDSH activists were engaged to buy these newspapers because of the text "Sadi Bexheti, spy of DBK".
Tom raved about the performance of DBK's knives and this was later backed up by a personal conversation with American Handgunner editor Roy Huntington.
THE CARDIFF office of construction property and development consultants DBK has reported significant growth with its portfolio increasing in construction value from pounds 7m to pounds 30m.
Project management company DBK Back has announced it is opening a new office in Wales because of the building boom in the capital.
Michelle Israel, housewares and luggage division merchandise manager, said the DBK line, which is manufactured and distributed by Lifetime Brands, is aimed not only at Boulud's fans but at serious cooks as well.