PKN1

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PKN1

A gene on chromosome 19p13.12 that encodes a PKC-related serine/threonine-protein kinase involved in various cellular processes, including regulation of intermediate filaments of the actin cytoskeleton, cell migration, tumour cell invasion and transcription regulation. PKN1 regulates the cytoskeletal network by phosphorylating VIM and neurofilament proteins (e.g., NEFH, NEFL and NEFM), inhibiting their polymerisation; it is a coactivator of androgen receptor.
References in periodicals archive ?
DBK is appointed as project manager on the development of the 260,000 sq ft state of the art production facility, which is credited with bringing a new generation of automotive manufacturing back to the Midlands heartlands, as well as acting as quantity surveyor to the project and providing CDMC services.
David Payne of Birmingham Properties Group, who was project manager for Harborne Central, said: "We are delighted to continue our association with DBK.
larinin (14) calismasinda, demir depolari yeterli olan anneler ile yetersiz olan anneler ve bunlarin yenidoganlari arasinda Hb, Htc, MCV, MCH, MCHC, demir, DBK, Tsat ve serum ferritin degerleri acisindan anlamli fark bulunamamistir.
DBK is appointed as cost consultant on both Wokingham Industrial Park and Anglo Business Park in Aylesbury.
DBK cookware is sold in open stock and in a 10-piece master set.
No matter what kind of accessories, these would all be available at discounted rates during the clearance sales at DBK.
Birmingham-based developer Graftongate has appointed DBK as cost consultant, employer's agent and CDM co-ordinator for the Dunfermline project, which is set to create 750 jobs and will be Amazon's largest UK fulfilment centre.
The office will be headed up by newly-promoted regional director Andrew Lewis, who has been working out of DBK Goyne Adams's London office for the past four years.
DBK Back will act as project manager and quantity surveyor for the project.
DBK, launched by the chef in fall 2003, currently includes cookware, cutlery, bakeware, kitchenware, tableware, kitchen textiles and seasoning collections.
DBK loan funds and capital raised by the Eurasian Group allow commissioning of a ferroalloy plant built from scratch, and reduction of production costs by using new technologies.
DBK has been appointed by student accommodation provider Alumno to support three new high-profile projects across the UK.