DAX1


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DAX1

A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY.

Molecular pathology
DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
References in periodicals archive ?
Jameson, "Presymptomatic diagnosis of X-linked adrenal hypoplasia congenita by analysis of DAX1," Journal of Pediatrics, vol.
Clinical case seminar: an amino-terminal DAX1 (NROB1) missense mutation associated with isolated mineralocorticoid deficiency," Journal of Clinical Endocrinology and Metabolism, vol.
Mendonca, "Clinical case seminar: adrenocorticotropin-dependent precocious puberty of testicular origin in a boy with X-linked adrenal hypoplasia congenita due to a novel mutation in the DAX1 gene," Journal of Clinical Endocrinology and Metabolism, vol.
Similarly, little evidence of the exercise of market power through strategic withholding is evident in three of the four double auction markets (DA2, DAX1 and DA1).