DALM


Also found in: Acronyms.

DALM

Dysplasia-associated lesion/mass GI disease An acronym referring to ↑ incidence of colorectal CA with ulcerative colitis when the pathologist finds dysplasia and the endoscopist finds a tumor mass; DALM alone may be a sufficient criterion for performing a proctocolectomy
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Furthermore, the combination of p53, Ki-67, and [beta]-catenin could be a practical immunohistochemical panel to help distinguish DALM lesions from sporadic tubular adenomas.
In their study, 49% of patients had an adenoma-like DALM and 51% had sporadic adenomas.
Classification and Management of Dysplasia in Patients With Inflammatory Bowel Diseasea Diagnosis Surroundings Endoscopic Features Negative for Normal or None noted dysplasia colitis Indefinite for Colitis Variable dysplasia Sporadic Normal Conventional adenoma features of sessile or pedunculated adenoma Colitis Conventional features of pedunculated adenoma Adenoma-like Colitis Sessile, dysplastic endoscopically polyp resectable, dome-shaped, sharp boundaries, no gross stigmata of cancer DALM Colitis Nonresectable by polypectomy, poorly defined boundaries or stigmata of cancer Flat LGD Colitis None noted by endoscopist Flat HGD Colitis None noted by endoscopist Associated Diagnosis Precautions Cancer Risk Negative for NA Low (5-y rate: 1.
Genetic alterations in chronic ulcerative colitis-associated adenoma-like DALMs are similar to non-colitic sporadic adenomas.