DAF16

DAF16

A gene first identified in Caenorhabditis elegans and later found in other species including humans, which is related to the fork-head genes that encode proteins that attach to and control DNA. DAF16 is associated with a 2-fold increase in the lifespan of C. elegans and may control longevity in humans.
References in periodicals archive ?
Mori, "Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF16 homologues," Biochemical Journal, vol.
Zurawski et al., "Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF16 in the model organism Caenorhabditis elegans," Archives of Toxicology, vol.
[43], where a treatment of 100 [micro]M EGCG for 48 h increased (2.2-fold) the amount of worms showing predominantly nuclear localisation of DAF16 in contrast to untreated C.
coli OP50, and the following transgenic worms: CB1370, daf-2 (e1370); TJ1052, age-1 (hx546); CF1038, daf16 (mu86); MQ1333, nuo-6 (qm200); MQ887, isp-1 (qm150); DA465, eat-2 (ad465); RB1206, rsks-1 (ok1255) and CF1903, glp-1 (e2144).